Luke Engelking, MD, PhD

Dr. Engelking a physician-scientist gastroenterologist, genetic cancer specialist, investigator, and educator. He serves as the Co-Medical Director of UT Southwestern's Cancer Genetics program and its Genetic Cancer Prevention Clinic, where he is accepting new patient referrals (ph: 214-645-2563; f: 214-645-2562).
He leads clinic, endoscopy, and research programs focused on hereditary syndromes of GI cancer risk and polyposis, such as Lynch syndrome and Familial Adenomatous Polyposis syndrome. The overarching goal of these programs is cancer prevention care for patients and their families with inherited forms of GI cancers, particularly colorectal cancer. He has completed intensive training from City of Hope and is a certified genetic cancer risk assessment specialist.
He completed joint MD/PhD training (2000-2007) at UT Southwestern in Dallas, where he studied cholesterol metabolism under Nobel Laureates Goldstein and Brown. He next completed internal medicine training at Massachusetts General Hospital (2007-2010), an affiliate of Harvard Medical School, and then returned to UT Southwestern for a clinical and research fellowship in gastroenterology (2010-2014). He is now an Associate Professor of Internal Medicine and the Harold C. Simmons Comprehensive Cancer Center. He served as interim Associate Dean of Medical Student Research and Scholarly Activity. His basic science laboratory studied various aspects of lipid metabolism in digestive organs and GI tract neoplasms, supported by research grants from NIH and CPRIT. He has authored numerous high impact research manuscripts published in Journal of Clinical Investigation, Cell Metabolism, and elsewhere.
Dr. Engelking has particular expertise in the care of the following genetic conditions: Lynch syndrome, Familial Adenomatous Polyposis syndrome, MUTYH-associated Polyposis syndrome, Peutz-Jeghers syndrome, Juvenile Polyposis syndrome, Cowden syndrome, Serrated Polyposis syndrome, Colonic Polyposis of Unknown Etiology, and other genetic disorders of GI cancer risk.
Financial relationships
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Type of financial relationship:There are no financial relationships to disclose.Date added:12/13/2021Date updated:01/15/2026
**Disclaimer**
This Continuing Medical Education (CME) Learning Management System, Ethos, includes individuals designated as 'faculty' for CME purposes. Please note that the term 'faculty' refers solely to their role as a contributor/planner within a CME activity and does not imply any formal affiliation with UT Southwestern Medical Center (UTSW). The display of names and credentials is intended for educational purposes only and does not necessarily indicate a professional or academic relationship with UTSW. Participants are encouraged to verify the affiliations and credentials of faculty members independently if further clarification is needed.

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