Jan Grimm is an Attending and Professor in Radiology and Member of the Molecular Pharmacology Program in MSKCC. He is also a Professor of Pharmacology in Weil Cornell Medical College. His Lab focuses on the development of novel imaging and therapy approaches for cancer. His lab was the first to utilize PET tracers clinically for Cerenkov imaging and is developing new approaches for this novel modality. He strives to develop novel concepts on how to image biological events, understanding the biological basis while simultaneously keeping clinical translatability within sight. This drive led to the discovery of an unknown yet important oncogenic role of PSMA in prostate cancer. The lab recently developed a novel therapeutic approach with nanoparticles, oxidative ferrotherapy, utilizing clinical approved iron oxide nanoparticles for leukemia therapy and is exploring the interaction of nanoparticles with the cancer microenvironment. It has also developed the new modality of multiplexed PET imaging.

As an expert in the field of imaging and board certified nuclear medicine physician and radiologist with experience in both clinical radiology and basic science, Dr. Grimm received his medical degree from the University of Hamburg and his PhD from the University of Schleswig-Holstein, both in Germany. He was a postdoctoral fellow and later faculty in the Center for Molecular Imaging research at MGH in Boston from 2002-2006 and joined MSKCC in 2006, where he became a full Professor In 2019. He authored numerous articles, is NIH funded and received several awards for his work. He is also an elected member of the American Society for Clinical Investigation and Associate Editor for the Journal of Nuclear Medicine .