EM2503E "Optimal Blood Pressure Targets with Age: From SHEP to ESPRIT" (IM GR - 031425)

Overview

Purpose and Overview

The Systolic Blood Pressure Intervention Trial (SPRINT; ClinicalTrials.gov, NCT01206062) was stopped early because of significantly lower risk of cardiovascular disease in participants randomized to a systolic blood pressure (SBP) target of 120 mmHg (intensive) than in those randomized to 140 mmHg (standard). The cardiovascular outcome benefit was also identified in participants aged 75 and older assigned to the intensive arm—34% lower —in addition to 33% lower all-cause mortality at 3.14 years of follow-up. These beneficial outcomes held in older participants characterized as frail or with impaired gait speed. The SPRINT Memory and Cognition IN Decreased Hypertension – SPRINT MIND – study results from 2019 demonstrated a reduction in the incidence of mild cognitive impairment in the intensive group, but not in all-cause probable dementia. 

Target Audience

UT Southwestern faculty, fellows, residents and medical students, community physicians, nurse clinicians, physician assistants and nurses.

Learning Objectives

At the conclusion of this activity, the participant should be able to:

  • Be familiar with the randomized controlled trials (SHEP, HYVET, SPRINT, STEP and ESPRIT) that have informed our understanding of appropriate systolic blood pressure (SBP) targets for older adults.
  • Become familiar with modifiable approaches to prevent cognitive impairment including new results from the SPRINT-MIND study.
  • Recognize the potential mechanistic role for vascular stiffness and brain health
Course summary
Available credit: 
  • 1.00 AMA
Course opens: 
03/18/2025
Course expires: 
04/18/2025
Cost:
$0.00
Rating: 
0

Faculty

Photo: First Last, M.D.
Mark Supiano, M.D..
Professor of Internal Medicine
Division of Geriatrics
Director, Hospital Elder Life Program
University of Utah

Accreditation

Available Credit

  • 1.00 AMA

Register/Take course

Price

Cost:
$0.00
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Required Hardware/software

Activities should be run with recent versions of common browsers, including Internet Explorer, Firefox and Google Chrome