EM2605G"Genetics of Steatotic Liver Disease: Pathogenesis, Prognosis and Implications for Treatment" (IM GR-051526)

Purpose and Overview

Steatotic liver disease (SLD) is a leading cause of liver-related morbidity and mortality worldwide. Obesity, insulin resistance, and chronic alcohol intake are its major risk factors, but genetic differences strongly influence disease susceptibility. Human genetic studies have identified key genetic modifiers of SLD risk, both those that confer susceptibility and resistance, thereby deepening our understanding of disease pathogenesis.

Target Audience

UT Southwestern faculty, fellows, residents and medical students, community physicians, nurse clinicians, physician assistants and nurses.

Learning Objectives

At the conclusion of this activity, the participant should be able to:

  • Describe the physiologic basis of hepatic steatosis. 
  • Explain why PNPLA3(148M) is the genetic risk factor with the greatest clinical impact on steatotic liver disease (SLD).  
  • Summarize the current and emerging therapeutic strategies for the prevention and treatment of SLD.
Course summary
Available credit: 
  • 1.00 AMA
Course opens: 
05/21/2026
Course expires: 
08/21/2026
Cost:
$0.00
Rating: 
0

Dr. Helen Hobbs

Helen H. Hobbs, M.D., M.Sc.
Professor & Chief of Clinical Genetics
Dallas Heart Ball Chair in Cardiology Research
Department of Internal Medicine
UT Southwestern Medical Center

Available Credit

  • 1.00 AMA

Price

Cost:
$0.00
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