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ForwardEM2608F “Consumed by Disease: Insights from Cancer Cachexia”
Purpose and Overview...
This lecture provides a translational overview of cancer cachexia, integrating clinical observations with mechanistic laboratory studies to understand why patients with cancer develop progressive weight loss and tissue wasting. Using complementary epidemiologic, human, and experimental approaches, the presentation highlights the clinical impact and early occurrence of cachexia, identifies tumor-derived and host pathways that drive adipose and muscle wasting, and illustrates how discoveries involving STK11/LKB1, GDF15, and cytokine-mediated signaling in tissues can reveal biomarkers and therapeutic targets. Ultimately, the lecture demonstrates how the interplay between bedside observations and bench research can advance the diagnosis, mechanistic understanding, and potential treatment of cancer cachexia.
Target Audience
UT Southwestern faculty, fellows, residents and medical students, community physicians, nurse clinicians, physician assistants and nurses.
Learning Objectives
At the conclusion of this activity, the participant should be able to:
- Recognize the clinical features and consequences of cancer cachexia, including its occurrence across cancer types and stages and its association with adverse outcomes.
- Describe key mechanisms that drive cancer-associated tissue wasting, including tumor-derived factors and pathways that promote adipose and muscle loss.
- Discuss emerging therapeutic strategies for cancer cachexia and how mechanistic discoveries can be translated into tumor- and tissue-directed treatments.
Course summary
- 1.00 AMA
- 1.00 Attendance
Rodney Infante, M.D. Ph.D.
Assistant Professor of Internal Medicine
Division of Digestive and Liver Diseases
Available Credit
- 1.00 AMA
- 1.00 Attendance
Price
Required Hardware/software
Activities should be run with recent versions of common browsers, including Internet Explorer, Firefox and Google Chrome