Learning objectives:

1.    Describe the fundamental principles of sulfated glycan biology and their roles in healthy brain function and neuroimmune responses.

2.    Explain how genetic susceptibility and environmental factors, including infection and inflammation, may drive sulfated glycan remodeling and influence neuroimmune responses and tau pathology in Alzheimer’s disease and other tauopathies.

3.    Evaluate the translational potential of sulfated glycan biology for biomarker development and novel diagnostic and therapeutic approaches in neurodegenerative disease.