BIOGRAPHICAL SKETCH

Provide the following information for the Senior/key personnel and other significant contributors.

Follow this format for each person. DO NOT EXCEED FIVE PAGES.

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)

A. Personal Statement

I am a midlevel academic transplant nephrologist and clinical researcher with expertise in comparative effectiveness research methods, specifically in health economics, decision sciences, cost analyses and patient-centered outcome measurements. In my main program of research, my interdisciplinary team has examined efficiency in multi-organ allocation, decreasing discard rate of organs, and economical analysis of induction therapy in kidney transplantation. My research team is composed of Burhaneddin Sandikci PhD (Associate Professor of Operations Management, University of Chicago, Booth School of Business, Chicago, Illinois), Mehmet Ayvaci PhD (Assistant Professor Information Systems, Naveen Jindal School of Management, the University of Texas at Dallas, Dallas, Texas), and Mutlu Mete PhD (Associate Professor, Department of Computer Science, Texas A&M University-Commerce, Commerce, Texas). I also closely work with Dr. Ricardo La Hoz on establishing comprehensive transplant dataset & health analytic tools. I have the expertise, leadership, training, and motivation necessary to successfully carry out the proposed research projects of Dr. Ananth Madhuranthakam in regards to subject enrollment, interpretation of clinical data, and statistical analysis. I have a broad background in nephrology, with specific training and expertise in transplant nephrology and secondary data analysis.

1. Tanriover B, Fernandez S, Campenot ES, Newhouse JH, Oyfe I, Mohan P, Sandikci B, Radhakrishnan J, Wexler JJ, Carroll MA, Sharif S, Cohen DJ, Ratner LE, Hardy MA. Live Donor Renal Anatomic Asymmetry and Posttransplant Renal Function. Transplantation. 2015 Aug;99(8):e66-74. PubMed PMID: 25719258; PubMed Central PMCID: PMC4549234.
2. Tanriover B, Mejia A, Weinstein J, Foster SV, Ghalib R, Mubarak A, Cheng SS. Analysis of kidney function and biopsy results in liver failure patients with renal dysfunction: a new look to combined liver kidney allocation in the post-MELD era. Transplantation. 2008 Dec 15;86(11):1548-53. PubMed PMID: 19077888.

B. Positions and Honors

Positions and Employment

Other Experience and Professional Memberships

Honors

C. Contribution to Science

1. These publications mainly addressed outcomes (overall graft survival and acute rejection at one-year) according to induction therapy used in renal transplant recipients maintained on contemporary immunosuppression. We also analyzed the cost-effectiveness of induction therapy in deceased donor kidney transplant setting for Medicare primary patients. Our findings showed that utility of IL-2 receptor blocker induction has significantly decreased in the setting tacrolimus/mycophenolate maintenance.
   1. Gharibi Z, Ayvaci MUS, Hahsler M, Giacoma T, Gaston RS, Tanriover B. Cost-Effectiveness of Antibody-Based Induction Therapy in Deceased Donor Kidney Transplantation in the United States. Transplantation. 2017 Jun;101(6):1234-1241. PubMed PMID: 27379555; PubMed Central PMCID: PMC4935932.
   2. Tanriover B, Jaikaransingh V, MacConmara MP, Parekh JR, Levea SL, Ariyamuthu VK, Zhang S, Gao A, Ayvaci MU, Sandikci B, Rajora N, Ahmed V, Lu CY, Mohan S, Vazquez MA. Acute Rejection Rates and Graft Outcomes According to Induction Regimen among Recipients of Kidneys from Deceased Donors Treated with Tacrolimus and Mycophenolate. Clin J Am Soc Nephrol. 2016 Sep 7;11(9):1650-61. PubMed PMID: 27364616; PubMed Central PMCID: PMC5012491.
   3. Tanriover B, Zhang S, MacConmara M, Gao A, Sandikci B, Ayvaci MU, Mete M, Tsapepas D, Rajora N, Mohan P, Lakhia R, Lu CY, Vazquez M. Induction Therapies in Live Donor Kidney Transplantation on Tacrolimus and Mycophenolate With or Without Steroid Maintenance. Clin J Am Soc Nephrol. 2015 Jun 5;10(6):1041-9. PubMed PMID: 25979971; PubMed Central PMCID: PMC4455215.
   4. Tsapepas DS, Mohan S, Tanriover B, Dube G, Crew RJ, Cohen DJ, Hardy MA, Sandoval PR, Ratner LE. Impact of small variations in the delivered dose of rabbit antithymocyte induction therapy in kidney transplantation with early corticosteroid withdrawal. Transplantation. 2012 Aug 27;94(4):325-30. PubMed PMID: 22814328.
2. In addition to the contributions described above, with a team of collaborators, we studied marginal deceased donor kidney utilization pattern in the US and showed the possibility of dual kidney transplant allocation and a decrease in the discard of the kidneys. Currently, the United Network for Organ Sharing Kidney Committee is working on a policy change based on several publications including ours.
   1. Chiles MC, Husain SA, Skillen W, Lee S, Carpenter D, Pastan SO, Patzer RE, Tanriover B, Mohan S. Predictive Value of Using Initial Versus Terminal Deceased Donor Creatinine to Calculate the Kidney Donor Risk Index. Am J Kidney Dis. 2017 Apr 14;PubMed PMID: 28416320.
   2. Torlak F, Ayvaci MU, Ahsen ME, Arce C, Vazquez MA, Tanriover B. Estimating Waiting Time for Deceased Donor Renal Transplantion in the Era of New Kidney Allocation System. Transplant Proc. 2016 Jul-Aug;48(6):1916-9. PubMed PMID: 27569922.
   3. Tanriover B, Mohan S, Cohen DJ, Radhakrishnan J, Nickolas TL, Stone PW, Tsapepas DS, Crew RJ, Dube GK, Sandoval PR, Samstein B, Dogan E, Gaston RS, Tanriover JN, Ratner LE, Hardy MA. Kidneys at higher risk of discard: expanding the role of dual kidney transplantation. Am J Transplant. 2014 Feb;14(2):404-15. PubMed PMID: 24472195; PubMed Central PMCID: PMC4058786.
   4. Mohan S, Tanriover B, Ali N, Crew RJ, Dube GK, Radhakrishnan J, Hardy MA, Ratner LE, McClellan W, Cohen D. Availability, utilization and outcomes of deceased diabetic donor kidneys; analysis based on the UNOS registry. Am J Transplant. 2012 Aug;12(8):2098-105. PubMed PMID: 22758926; PubMed Central PMCID: PMC3409306.
1. Decision making for kidney allocation in the multi-organ transplant setting is center specific and there is no an UNOS policy. Our publications described that dialysis at the time of transplant and organ quality are the major determinant of patient survival in the setting of combined liver-kidney transplantation. New allocation policies by the UNOS committee are in progress.
   1. Ariyamuthu VK, Amin AA, Drazner MH, Araj F, Mammen PPA, Ayvaci M, Mete M, Ozay F, Ghanta M, Mohan S, Tanriover B. Induction regimen and survival in simultaneous heart-kidney transplant recipients. J Heart Lung Transplant. 2017 Nov 15. Pii: S1053-2498(17)31951-4. PMID:29198930.
   2. Banga A, Mohanka M, Mullins J, Bollineni S, Kaza V, Torres F, Tanriover B. Association of pretransplant kidney function with outcomes after lung transplantation. Clin Transplant. 2017 May;31(5)PubMed PMID: 28196295.
   3. Rich N, Tanriover B, Singal AG, Marrero JA. Outcomes of Simultaneous Liver Kidney Transplantation in Patients With Hepatocellular Carcinoma. Transplantation. 2017 Jan;101(1):e12-e19. PubMed PMID: 28009759.
   4. Tanriover B, MacConmara MP, Parekh J, Arce C, Zhang S, Gao A, Mufti A, Levea SL, Sandikci B, Ayvaci MU, Ariyamuthu VK, Hwang C, Mohan S, Mete M, Vazquez MA, Marrero JA. SIMULTANEOUS LIVER KIDNEY TRANSPLANTATION IN LIVER TRANSPLANT CANDIDATES WITH RENAL DYSFUNCTION: IMPORTANCE OF CREATININE LEVELS, DIALYSIS, AND ORGAN QUALITY IN SURVIVAL. Kidney Int Rep. 2016 Nov;1(4):221-229. PubMed PMID: 27942610; PubMed Central PMCID: PMC5138564.

Complete List of Published Work in My Bibliography:

https://www.ncbi.nlm.nih.gov/pubmed/?term=tanriover+b

D.        Additional Information: Research Support and/or Scholastic Performance

Ongoing Research Support

None

Completed Research Support

1. KM1 Junior Faculty Career Development Grant on Comparative Effectiveness Research: NIH-1KM1CA156709-01(MPI), received on 07/01/2011. PI: Melissa Begg, MD at Columbia University Health Sciences, New York, NY.

2. Irving Institute/Clinical Trials Office (CTO) Pilot Award, CTSA at Columbia University in July 2012; the project entitled “Effect of living kidney donation on metabolic state and insulin sensitivity”.