Luc Brion, MD
During my training in pediatrics and in neonatology, I participated and conducted studies on growth, anthropometry, nutrition and assessment of renal function in neonates and children. As Faculty at AECOM I was funded for years by the NIDDK, American Heart Association, Genentech Foundation, and Pharmacia for basic sciences research in developmental nephrology, specifically renal acid secretion, carbonic anhydrase, pathophysiological effects of acidosis and growth. My academic focus later changed to education as fellowship training director and to clinical research assessing neonatal mortality and morbidity and evidence-based medicine. I completed several Cochrane reviews (including diuretics for lung disease in neonates) and participated in 2 randomized controlled trials (RCTs) in preterm infants. I was the US representative for the COIN trial, which is the first large international randomized trial comparing endotracheal intubation versus continuous positive airway pressure in the delivery room for very preterm infants.
In 2006 I moved from New York to UT Southwestern (UTSW) at Dallas to become the director of the large fellowship training program in neonatal-perinatal medicine at UTSW; this responsibility took most of my time until we recruited an Associate Program director. I am the Alternate PI of the NICHD Neonatal Research Network (NRN) for UTSW and am co-author of 2 published NRN RCTs, one on vitamin E and one on inositol. I initiated two studies in preterm infants: (1) a bundle quality improvement project designed to optimize nutrition and growth based on weight gain, linear growth (using a validated method), BMI and serum and urine biochemistry and (2) an RCT designed to assess whether targeted fortification of human milk (based on daily measurements of macronutrients in mothers’ own milk) improves linear growth and reduces disproportionate growth compared with individualized nutrition (based on growth rate and serum measurements) (https://clinicaltrials.gov/ct2/show/NCT02372136?term=02372136&rank=1).
Among 32 physicians I have been mentoring, 30 have completed their training and 29 have published at least one manuscript as a result of this mentorship.