Dr. Matthews grew up as an Army brat and attended Williams College where she was an English major and rowed varsity crew for four years. She attended the Medical College of Virginia for medical school and residency, and first came to Texas in 1989 for a fellowship in Gynecologic Oncology at the University of Texas MD Anderson Cancer Center. She was persuaded to stay in Texas, joining the faculty at Baylor University Medical Center in 1991. She has had many roles on the faculty at Baylor- residency program director, Cancer center QA director, medical staff president, and has been  Director of Integrative and Functional Medicine since 2010. 

In addition to Gynecologic Oncology, she is board certified in Integrative Medicine and is certified in Functional Medicine. In her spare time, Dr. Matthews helps her husband and son manage a farm raising purebred, grass fed Red Devon cattle.