ZHIKAI CHI, MD. Ph.D.

Curriculum vitae

Date Prepared:	01/04/2019
Name:	Zhikai Chi
Office Address:	5323 Harry Hines Blvd, NPH02-950 Dallas, Texas, 75390-9073
Work Phone:	469-491-3398
Work E-Mail:	zhikai.chi@utsouthwestern.edu
Work Fax:
Place of Birth:	China

Education

Year	Degree (Honors)	Field of Study (Thesis advisor for PhDs)	Institution
1995–1998	Undergraduate	Pre-medicine	Peking University, China
1998–2003	M.D.	Medicine	Peking Union Medical College, China
2003–2009	Ph.D.	Thesis Advisors: Dr. Ted M. Dawson	The Johns Hopkins University School of Medicine, Baltimore, MD

Postdoctoral Training [Include residency/fellowship]

Year(s)	Titles	Specialty/Discipline (Lab PI for postdoc research)	Institution
2009–2013	Research Fellow	PI: Dr. Valina L. Dawson	The Johns Hopkins University School of Medicine, Baltimore, MD
2013–2017	Resident	Anatomic and Clinical Pathology	Indiana University School of Medicine, Indianapolis, IN
2017–2018	Clinical Fellow	Gastroenterology/Liver Pathology	Cedars-Sinai Medical Center, Los Angeles, CA

Current Licensure and Certification

Licensure

Texas medical license (2018–2020)

California medical license (2015–2019)

Board and Other Certification

American Board of Pathology: Anatomic and Clinical Pathology (2017–2027)

Honors and Awards

Year	Name of Honor/Award	Awarding Organization
1998–2000	Fellowship in basic medicine phase	Peking Union Medical College, China
2002–2002	Fellowship in clinical medicine phase	Peking Union Medical College, China
2003–2003	Graduate with honor	Peking Union Medical College, China
2003–2003	Vernon Mountcastle Graduate Fellowship in the Neurosciences	The Johns Hopkins University School of Medicine, Baltimore, MD
2003–2005	Neuroscience graduate fellowship	The Johns Hopkins University School of Medicine, Baltimore, MD
2006–2008	Pre-doctoral research fellowship	American Heart Association

Faculty Academic Appointments

Year(s)	Academic Title	Department	Academic Institution
2018–	Assistant Professor	Pathology	UT Southwestern Medical Center, Dallas, TX

Appointments at Hospitals/Affiliated Institutions

Past
Year(s)	Position Title	Department/Division	Institution


Current
Year(s)	Position Title	Department/Division	Institution
2018–	Staff Pathologist	Pathology	UTSW University Hospitals, Dallas, TX
2018–	Staff Pathologist	Pathology	Parkland Memorial Hospital, Dallas, TX
2018–	Staff Pathologist	Pathology	Children’s Medical Center, Dallas, TX

Other Professional Positions [Industry, foundation, private practice]

Year(s)	Position Title	Institution

Major Administrative/Leadership Positions

Year(s)	Position Title	Institution

Committee Service

Year(s)	Name of Committee	Institution/Organization
UTSW


Hospital


State/Regional


National/International

Professional Societies [List all society committees, leadership, and course leadership roles here]

Dates	Society Name, member
2013–	United States and Canadian Academy of Pathology
2017–	College of American Pathologists
	Committees
	Fellowships

Grant Review Activities

Year(s)	Name of Review Committee	Organization

Editorial Activities

Year(s)	Journal Name
Editor/Associate Editor

Editorial Board

Ad Hoc Reviewer

Invited Lectures

Year(s)	Title	Location
International
2009	“The Novel Protein Botch Promotes Neurogenesis through Notch Signaling Pathway.”	World Stem Cell Summit, Baltimore, MD

National


Regional/Local

Technological and Other Scientific Innovations

Innovation

Patent, if any, pending or awarded /If described in print/on web, provide citation

Teaching activities

Year(s)	Title	Locations
2018	GI/liver medical fellow slides teaching (8/1)	Parkland Memorial Hospital
2018	Liver transplant fellow slides teaching (8/13)	Parkland Memorial Hospital
2018	Pathology resident teaching conference (9/18)	Parkland Memorial Hospital
2019	UTSW medical school - Pathology laboratory teaching (1/8, 2/18, 4/22, 5/13, 5/14)	UTSW
2019	UTSW medical school - Frontiers in Medicine Neoplasia (group teaching, 3hr total, 2/13 and 2/14)	UTSW
2019	GI/liver medical fellow teaching (2/27, 5/1)	Parkland Memorial Hospital

Service to the Community

Year(s)	Role	Organization or institution
2018	Designated GI/Liver DOT Pathologist, activities include reviewing cases for clinical trials (10 cases) and participating monthly DOT research conferences	UTSW
2018	Pathology fellow candidate interview (3 candidates)
2018	Pathology faculty candidate interviews (1 candidate)	UTSW
2019	Designated GI/Liver DOT Pathologist, activities including reviewing cases for clinical trials (1 cases) and participating monthly DOT research conferences	UTSW
2019	Pathology resident candidate interviews (3 candidates)	UTSW
2019	Pathology faculty candidate interviews (2 candidates)	UTSW

Bibliography

Peer-Reviewed Publications

Original Research Articles

	Gong Y, Wu J, Qiang H, Liu B, Chi Z, Chen T, Yin B, Peng X, Yuan J. BRI3 associates with SCG10 and attenuates NGF-induced neurite outgrowth in PC12 cells. BMB Rep, 41(4):287-93 (2008)
	Albéri L, Chi Z, Kadam SD, Mulholland JD, Dawson VL, Gaiano N, Comi AM. Neonatal stroke in mice causes long-term changes in neuronal activity and Notch2 expression. Stroke. 41(10 Suppl): S64-71 (2010)
	Zhang J, Wang Y, Chi Z, Keuss MJ, Pai YM, Kang HC, Shin JH, Bugayenko A, Wang H, Xiong Y, Pletnikov MV, Mattson MP, Dawson TM, Dawson VL. Thorase, A Novel AAA+ ATPase, Regulates AMPA Receptor-Dependent Synaptic Plasticity and Behavior. Cell. 2011 Apr 15;145(2):284-99
	Andrabi SA, Kang HC, Haince JF, Lee YI, Zhang J, Chi Z, West AB, Koehler RC, Poirier GG, Dawson TM, Dawson VL. Iduna Protects the Brain from Glutamate Excititoxicity and Stroke by Interfering with Parthanatos (Poly (ADP-ribose) Dependent Cell Death). Nature Medicine. 2011 Jun;17(6):692-9
	Kang HC, Lee YI, Shin JH, Andrabi SA, Chi Z, Gagné JP, Lee Y, Ko HS, Lee BD, Poirier GG, Dawson VL, Dawson TM. Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage. Proc Natl Acad Sci of USA. 2011 Aug 23;108(34):14103-8
	Chi Z, Zhang J, Tokunaga A, Harraz MM, Byrne ST, Dolinko A, Xu J, Blackshaw S, Gaiano N, Dawson TM, Dawson VL. Botch promotes neurogenesis by antagonizing notch. Developmental Cell. 2012 Apr 17;22(4):707-20
	Chi Z, Byrne T, Dolinko A, Maged M., Kim M, Umanah G, Zhong J, Chen R, Zhang J, Xu J, Chen L, Pandey A, Dawson TM, Dawson VL. Botch is a gamma-Glutamyl Cyclotransferase that Deglycinates and Antagonizes Notch. Cell Reports. Cell Reports 7, 1–8, May 8, 2014
	Xu J, Fan J, Wang X, Eacker S, Kam T, Chen L, Zhu J, Chi Z, Jiang H, Chen R, Dawson TM, Dawson VL. Parthanatos Mediates Human Neuronal Neurotoxicity as Revealed through Functional Human Cortical Excitatory and Inhibitory Networks. Sci Transl Med. 2016 Apr 6;8(333):333ra48
	Zhang J, Wang H, Sherbini O, Ling-Lin Pai E, Kang SU, Kwon JS, Yang J, He W, Wang H, Eacker SM, Chi Z, Mao X, Xu J, Jiang H, Andrabi SA, Dawson TM, Dawson VL. High-Content Genome-Wide RNAi Screen Reveals CCR3 as a Key Mediator of Neuronal Cell Death. eNeuro. 2016 Oct 24;3(5).
	Chi Z, Wu HH, Cramer H, Lin J, Chen S. Cytomorphological Features Useful to Prevent Errors in the Diagnosis of Pancreatic Adenocarcinoma by Fine Needle Aspiration Cytology. Acta Cytol. 2017;61(1):7-16.
	Zhang J, Yang J, Wang H, Sherbini O, Keuss MJ, Umanah GK, Pai EL, Chi Z, Paldanius KM, He W, Wang H, Andrabi SA, Dawson TM, Dawson VL. The AAA + ATPase Thorase is neuroprotective against ischemic injury. J Cereb Blood Flow Metab. 2018 Jan 1:271678X18769770
	Chi Z, Mangus RS, Kubal CA, Chen S, Lin J. Multivisceral transplant is a viable treatment option for patients with non-resectable intra-abdominal fibromatosis. Clin Transplant. 2018 Mar;32(3):e13186
	Chi Z, Bhalla A, Saeed O, Cheng L, Curless K, Wang HL, Patil DT, Lin J. Mucinous intrahepatic cholangiocarcinoma: a distinct variant. Hum Pathol. 2018 Aug;78:131-137.

Reviews, Chapters, Monographs and Editorials

Books/Textbooks

Case Reports

Letters to the Editor

Proceedings of Meetings

	Chi Z, Wu HH, Cramer H, Lin J, Chen S. Cytomorphological Features Useful for Diagnosing Pancreatic Adenocarcinoma on Fine Needle Aspirates: A Retrospective Study of Five Misdiagnosed Cases. (ASC's 63rd Annual Scientific Meeting 2015)
	Chi Z, Mangus RS, Chen S, Lin J. Multivisceral Transplant is a Viable Treatment for Patients with Unresectable Intraabdominal Fibromatosis. (USCAP 2016)
	Chi Z, Saxena R. Mast Cells in Microscopic Colitis: A Potential Therapeutic Targetrs? (USCAP 2017)
	Chi Z, Bhalla A, Wang HL, Patil DT, Lin J. Mucinous Variant of Intrahepatic Cholangiocarcinoma: A Clinicopathological and Immunochemical Study. (USCAP 2017)
	Chi Z, Larson BK, Guindi M. Argininosuccinate Synthase 1 (ASS1) is a Prognostic Marker for Tumor Hemorrhage in Inflammatory and β-Catenin-Mutated Hepatocellular Adenoma. (USCAP 2018)
	Chi Z, Larson BK, Guindi M. Argininosuccinate Synthase 1 (ASS1) Identifies a Novel Subtype of Hepatocellular Adenoma (HCA) Prone to Hemorrhage with High Sensitivity and Specificity. (USCAP 2018)
	Chi Z, Mertens R, Dhall D.Do Frozen Sections Make a Difference in the Surgical Management of Intraductal Papillary Mucinous Neoplasms of the Pancreas? (USCAP 2018)
	Arcega RS, Dhall D, Chi Z, Gaddam S, Waters KM. Mural Nodules in Intraductal Papillary Mucinous Neoplasms: Gross and Histopathologic Correlates (USCAP 2018)
	Wong M, Guindi M, Chi Z, Dhall D, Kim S, Larson B, Mertens RB, Taguibao RA, Waters KM. Interobserver Agreement and the Utility of Immunohistochemistry (IHC) for Assessing Tumor Budding in Colorectal Adenocarcinoma (USCAP 2019)
	Makhoul E, Chi Z, Dhall D, Waters KM. Evaluation for Serrated Epithelial Changes (SEC) in Prior Biopsies of Patients with Inflammatory Bowel Disease (IBD) Associated Flat Dysplasia (USCAP 2019)

Clinical Practice Guidelines

Non-peer reviewed scientific or medical publications/materials in print or other media

Financial relationships

There are no financial relationships to disclose.

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This Continuing Medical Education (CME) Learning Management System, Ethos, includes individuals designated as 'faculty' for CME purposes. Please note that the term 'faculty' refers solely to their role as a contributor/planner within a CME activity and does not imply any formal affiliation with UT Southwestern Medical Center (UTSW). The display of names and credentials is intended for educational purposes only and does not necessarily indicate a professional or academic relationship with UTSW. Participants are encouraged to verify the affiliations and credentials of faculty members independently if further clarification is needed.

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ZHIKAI CHI, MD. Ph.D.

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