Dr. Eisch is a tenured Professor in the Department of Anesthesiology and Critical Care at the Children’s Hospital of Philadelphia (CHOP) and in the Department of Neuroscience at the University of Pennsylvania Perelman School of Medicine (PennMed). She is interested in how molecular, cellular, and circuit changes—particularly in the limbic system—influence cognition and motivated behavior. She received her undergraduate degree from Yale University and her PhD in Neuroscience from the University of California at Irvine. During her postdoctoral studies at Yale University Medical School, Dr. Eisch first identified the negative consequences of drugs of abuse on the birth of new neurons in the adult hippocampus. This finding opened the possibility that new neurons in the adult brain were involved in addiction, and that harnessing the regenerative power of adult neurogenesis may be helpful in treating addiction. When she established her independent basic research lab at UT Southwestern Medical Center in 2000, Dr. Eisch and her team developed genetic approaches to dissect circuit mechanisms underlying behavior. They generated inducible transgenic mouse lines for fate-tracking and genetic manipulation of adult neural stem cells in vivo, and worked with many approaches to genetically modify selective cell populations (e.g. image-guided cranial irradiation and viral-mediated gene transfer to target new neurons) to determine their behavioral relevance. Dr. Eisch was recruited to CHOP/PennMed in 2016. The current Eisch Lab research still studies hippocampal neurogenesis, but merely as one of many indices of the “health” of dentate gyrus, with the lab’s primary focus on inducible alteration of neural circuits with relevance to normal and pathological behavior, such as addiction and depression. Dr. Eisch has >100 publications and given ~150 national and international presentations on her NIDA-, NARSAD-, and NASA-funded research. Dr. Eisch has received numerous honors, including in 2011 being named the inaugural Seymour Benzer Lecturer by the US National Academy of Sciences, and many teaching and mentoring awards. Dr. Eisch is exceptionally pleased to have helped train the next generation of neuroscientists, as ~100 trainees have worked in the Eisch Laboratory since 2000, many whom remain in science and are neuroscience pioneers.