Dr. Mathews completed training in pediatrics, child neurology and medical genetics, all at the University of Iowa.  She remains at the University of Iowa where she is a Professor of Pediatrics and Neurology, and Vice Chair for Clinical Investigation in the Department of Pediatrics. She directs the pediatric neuromuscular program and co-directs the U of Iowa Muscular Dystrophy Association clinic.   She began her research career in basic science and contributed to the genetic mapping of facioscapulohumeral dystrophy (FSHD). She subsequently transitioned to clinical research and is funded by the NIH and CDC, in addition to serving as site PI for many industry-sponsored clinical trials and foundation-supported studies.  She sees both pediatric and adult patients with a wide range of neuromuscular diseases in clinic.  Her goal throughout these activities has been to improve care of children and adults with neuromuscular diseases and to support development of the next generation of physicians and researchers.