Neil Rofsky, MD, MHA, FSABI, FACR, FISMRM
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)
INSTITUTION AND LOCATION DEGREE
(if applicable) Completion Date
MM/YYYY FIELD OF STUDY
University of Maryland, College Park, MD BS 05/1981 Biochemistry
New York Medical College, Valhalla, NY
Robert Wood Johnson Med Center, New Brunswick, NJ
University of Utah Medical Center, Salt Lake City UT
New York University Medical Center, New York NY
New York University Medical Center, New York NY
Columbia University, New York, NY
Intern: Internal Medicine
Fellow: Nuclear Medicine
Resident: Diagnostic Radiology
A. Personal Statement
As Chairman of the Department of Radiology at UT Southwestern Medical Center (UTSW), I oversee all of the clinical, educational and research activities for the department and allocate resources in order to achieve the mission of the Department: “...to translate innovations in imaging, information technologies, and image-guided therapies so that we optimize patient outcomes”. Throughout my career I have addressed the theoretical, technical, and practical obstacles to utilizing a number of complex MRI methods as potential “biomarkers” for clinical studies. More recently I have been correlating these “imaging biomarkers” with spatially co-registered genomic and proteomic analyses of tissue samples. These general principles have been directly applied to my focus on prostate cancer research over the last 15 years. In 2019 I completed 2 consecutive three-year terms as Co-Director of the CISC at NCI, guiding how imaging can best interface with NCI clinical trials. Throughout my career, I have prioritized the development and mentorship of students, trainees and junior faculty in both scientific principles and behavioral skills in order to sustain professional success and satisfaction. At UTSW, I instituted a dedicated Research Day specifically featuring trainees’ research. I previously served as an instructor at the annual RSNA clinical trials methodology workshop for 3 years, teaching clinical trial design strategies to young investigators. I have the expertise, leadership, training, and motivation necessary to successfully fulfill my role in the proposed research effort.
1. de Bazelaire CM, Duhamel GD, Rofsky NM, Alsop DC. MR imaging relaxation times of abdominal and pelvic tissues measured in vivo at 3.0 T: preliminary results. Radiology.2004 Mar;230(3):652-659.PMID: 14990831.
2. Bloch BN, Furman-Haran E, Helbich TH, Lenkinski RE, Degani H, Kratzik C, Susani M, Haitel A, Jaromi S, Ngo L, Rofsky NM. Prostate cancer: accurate determination of extracapsular extension with high-spatial-resolution dynamic contrast- enhanced and T2-weighted MR imaging--initial results. Radiology. 2007 Oct;245(1):176-85. PMID: 17717328.
3. de Bazelaire C, Alsop DC, George D, Pedrosa I, Wang Y, Michaelson MD, Rofsky NM. Magnetic resonance imaging- measured blood flow change after antiangiogenic therapy with PTK787/ZK 222584 correlates with clinical outcome in metastatic renal cell carcinoma. Clin Cancer Res. 2008 Sep 1;14(17):5548-5554. PMID: 18765547.
4. Clavijo Jordan MV, Lo ST, Chen S, Preihs C, Chirayil S, Zhang S, Kapur P, Li WH, De Leon-Rodriguez LM, Lubag AJ, Rofsky NM, Sherry AD. Zinc-sensitive MRI contrast agent detects differential release of Zn(II) ions from the healthy vs. malignant mouse prostate. Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5464-71. PMID: 27562169
B. Positions and Honors
Positions and Employment
1985 - 1986 Intern, Middlesex University Hospital, Rutgers Medical School , New Brunswick, NJ
1986 - 1987 Fellow, Nuclear Medicine, University of Utah Medical Center, Salt Lake City, UT
1987 - 1991 Resident, Radiology, New York University Medical Center, New York, NY
1990 – 1991
1991 Fellow, Abdominal Imaging: CT, US, and MRI, NYU Medical Center, New York, NY
Board Certification: The American Board of Radiology
Board Certification: The American Board of Nuclear Medicine
1991 - 1992 Fellow, Magnetic Resonance Imaging, New York University Medical Center, New York, NY
1992 - 1998 Assistant Professor, Radiology, New York University School of Medicine, New York , NY
1995 - 2000 Director of Body MRI, New York University School of Medicine, New York , NY
1998 - 2000 Associate Professor, Radiology, New York University School of Medicine, New York, NY
2000 - 2009 Associate Professor, Radiology, Harvard Medical School, Boston, MA
2000 - 2010 Director of MRI, Beth Israel Deaconess Medical Center, Boston, MA
2009 - 2010 Professor, Radiology, Harvard Medical School, Boston, MA
2018 Professor and Chairman, Radiology, UT Southwestern (UTSW) Medical Center, Dallas, TX
Effie and Wofford Cain Distinguished Chair in Diagnostic Imaging, UTSW Medical Center, Dallas, TX
NIH/NCI Distinguished Service Award for Service as Co-Chair of the CISC, 2011-2018.
Other Experience and Professional Memberships
1997 Elected Fellow, Society of Computed Body Tomography and Magnetic Resonance
1999 Moncada Award of Research, Society of Computed Body Tomography and Magnetic Resonance, "MR Imaging of hepatocellular carcinoma"
1999 Research Award, Society of Uroradiology, "MR Assessment of the Pelvic Floor"
2005 The Lauterber Award for an Outstanding Scientific Paper on Cross Sectional Imaging, SCBT/MR, "Rapid Body MRI Using IDEAL Water-fat Separation and Parallel Imaging"
2005 Cum Laude Award, Education Exhibit, Radiological Society of North America, "MRI Evaluation of Acute Right Lower Quadrant Pain"
2005 Developmental Project Award, Dana Farber Harvard Cancer Center Renal Cancer SPORE: "Improved magnetic resonance imaging of kidney tumor blood flow for monitoring or response to anti-angiogenic therapy"
2007 Elected Fellow, International Society of Magnetic Resonance in Medicine
2008 Cum Laude Award, SCBT/MR, "Increased Positive Yield with High Resolution 3T Prostate MRI prompted Biopsies"
2011 Elected Fellow, American College of Radiology
2012 Co-Director, Clinical Imaging Steering Committee, National Cancer Institute
2015 AOA, New York Medical College
C. Contribution to Science
1. Early in my career, I was focused on the development and evaluation of MR technology to evaluate anatomy and disorders of the cardiovascular system. This included seminal work in magnetic resonance angiography.
a. Rofsky NM, Weinreb JC, Grossi EA, Galloway AC, Libes RB, Colvin SB, Naidich DP. Aortic aneurysm and dissection: normal MR imaging and CT findings after surgical repair with the continuous-suture graft-inclusion technique. Radiology. 1993 Jan;186(1):195-201. PubMed PMID: 8416564.
b. Earls JP, Rofsky NM, DeCorato DR, Krinsky GA, Weinreb JC. Breath-hold single-dose gadolinium-enhanced three-dimensional MR aortography: usefulness of a timing examination and MR power injector. Radiology. 1996 Dec;201(3):705-10. PubMed PMID: 8939219.
c. Krinsky GA, Rofsky NM, DeCorato DR, Weinreb JC, Earls JP, Flyer MA, Galloway AC, Colvin SB. Thoracic aorta: comparison of gadolinium-enhanced three-dimensional MR angiography with conventional MR imaging. Radiology. 1997 Jan;202(1):183-93. PubMed PMID: 8988210.
d. Rofsky NM, Johnson G, Adelman MA, Rosen RJ, Krinsky GA, Weinreb JC. Peripheral vascular disease evaluated with reduced-dose gadolinium-enhanced MR angiography. Radiology. 1997 Oct;205(1):163-9. PubMed PMID: 9314979.
2. Recognizing the need for high performance 3D imaging we brought this from conceptualization into routine clinical practice, ultimately leveraging this capability to benefit prostate cancer evaluations. (see next page)
a. Rofsky NM, Lee VS, Laub G, Pollack MA, Krinsky GA, Thomasson D, Ambrosino MM, Weinreb JC. Abdominal MR imaging with a volumetric interpolated breath-hold examination. Radiology. 1999 Sep;212(3):876-84. PubMed PMID: 10478260.
b. Lee VS, Lavelle MT, Rofsky NM, Laub G, Thomasson DM, Krinsky GA, Weinreb JC. Hepatic MR imaging with a dynamic contrast-enhanced isotropic volumetric interpolated breath-hold examination: feasibility, reproducibility, and technical quality. Radiology. 2000 May;215(2):365-72. PubMed PMID: 10796909.
c. Lee VS, Rofsky NM, Morgan GR, Teperman LW, Krinsky GA, Berman P, Weinreb JC. Volumetric mangafodipir trisodium-enhanced cholangiography to define intrahepatic biliary anatomy. AJR Am J Roentgenol. 2001 Apr;176(4):906-8. PubMed PMID: 11264075.
d. Bloch BN, Furman-Haran E, Helbich TH, Lenkinski RE, Degani H, Kratzik C, Susani M, Haitel A, Jaromi S, Ngo L, Rofsky NM. Prostate cancer: accurate determination of extracapsular extension with high-spatial-resolution dynamic contrast-enhanced and T2-weighted MR imaging--initial results. Radiology. 2007 Oct;245(1):176-85. PubMed PMID: 17717328.
3. As interests migrated towards addressing the challenge of imaging the prostate and generating data that could aid in the important decisions MRI techniques were again developed and translated.
a. Bloch BN, Rofsky NM, Baroni RH, Marquis RP, Pedrosa I, Lenkinski RE. 3 Tesla magnetic resonance imaging of the prostate with combined pelvic phased-array and endorectal coils; Initial experience(1). Acad Radiol. 2004 Aug;11(8):863-7. PubMed PMID: 15288036.
b. Bloch BN, Rofsky NM, Baroni RH, Marquis RP, Pedrosa I, Lenkinski RE. 3 Tesla magnetic resonance imaging of the prostate with combined pelvic phased-array and endorectal coils; Initial experience (1). Acad Radiol. 2004 Aug; 11(8):863-867. PMID: 15288036.
c. Bloch BN, Genega EM, Costa DN, Pedrosa I, Smith MP, Kressel HY, Ngo L, Sanda MG, Dewolf WC, Rofsky NM. Prediction of prostate cancer extracapsular extension with high spatial resolution dynamic contrast-enhanced 3-T MRI. Eur Radiol. 2012 Oct;22(10):2201-10. PubMed PMID: 22661019.
d. Costa DN, Pedrosa I, Donato F Jr, Roehrborn CG, Rofsky NM. MR Imaging-Transrectal US Fusion for Targeted Prostate Biopsies: Implications for Diagnosis and Clinical Management. Radiographics. 2015 May-Jun; 35(3):696-708. doi: 10.1148/rg.2015140058. Epub 2015 Mar 18. Review. PMID:25786055.
4. Recognizing the importance of accelerating imaging times to reduce motion artifacts in body imaging and improve patient throughput, we were very involved in designing and implementing parallel imaging strategies.
a. McKenzie CA, Lim D, Ransil BJ, Morrin M, Pedrosa I, Yeh EN, Sodickson DK, Rofsky NM. Shortening MR image acquisition time for volumetric interpolated breath-hold examination with a recently developed parallel imaging reconstruction technique: clinical feasibility. Radiology. 2004 Feb;230(2):589-94. PubMed PMID: 14699184.
b. Zhu Y, Hardy CJ, Sodickson DK, Giaquinto RO, Dumoulin CL, Kenwood G, Niendorf T, Lejay H, McKenzie CA, Ohliger MA, Rofsky NM. Highly parallel volumetric imaging with a 32-element RF coil array. Magn Reson Med. 2004 Oct;52(4):869-77. PubMed PMID: 15389961; PubMed Central PMCID: PMC2819016.
c. Sodickson DK, Hardy CJ, Zhu Y, Giaquinto RO, Gross P, Kenwood G, Niendorf T, Lejay H, McKenzie CA, Ohliger MA, Grant AK, Rofsky NM. Rapid volumetric MRI using parallel imaging with order-of-magnitude accelerations and a 32-element RF coil array: feasibility and implications. Acad Radiol. 2005 May;12(5):626-35. PubMed PMID: 15866137; PubMed Central PMCID: PMC2819014.
d. Niendorf T, Hardy CJ, Giaquinto RO, Gross P, Cline HE, Zhu Y, Kenwood G, Cohen S, Grant AK, Joshi S, Rofsky NM, Sodickson DK. Toward single breath-hold whole-heart coverage coronary MRA using highly accelerated parallel imaging with a 32-channel MR system. Magn Reson Med. 2006 Jul;56(1):167-76. PubMed PMID: 16755538.
D. Research Support
Prior from 2002-2013
Attribution:SelfType of financial relationship:Professional ServicesIneligible company:BraccoTopic:Advisory BoardDate added:05/24/2022Relationship end date:05/17/2023
Attribution:SelfType of financial relationship:Professional ServicesIneligible company:Philips HealthcareTopic:Advisory BoardDate added:05/24/2022Relationship end date:06/30/2021
Attribution:SelfType of financial relationship:Professional ServicesIneligible company:InsightecTopic:Advisory BoardDate added:05/24/2022Relationship end date:07/21/2021