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ForwardPonciano Cruz, MD
Provide the following information for each individual included in the Research & Related Senior/Key Person Profile (Expanded) Form. | ||||
NAME PONCIANO D. CRUZ, JR., MD | POSITION TITLE DISTINGUISHED PROFESSOR | |||
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training). | ||||
INSTITUTION AND LOCATION | DEGREE (IF APPLICABLE) | YEAR(S) |
FIELD OF STUDY | |
University of the Philippines | B.S. | 1975 | Pre-medicine (cum laude) | |
University of the Philippines | M.D. | 1979 | Medicine (cum laude) | |
Wright State University/Kettering | Resident/ | 1981-84 | Internal Medicine | |
Medical Center | Chief Resident |
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University of Texas Southwestern Medical Center (UTSWMC) | Resident | 1984-86 | Dermatology | |
UTSWMC | Fellow | 1986-90 | Immunodermatology | |
RESEARCH AND PROFESSIONAL EXPERIENCE: POSITION AND EMPLOYMENT: Assist Professor, Dermatology, UTSWMC, Dallas,TX,1990-3 Director, Dermatology Residency Training Program, UTSWMC, Dallas, TX, 1991- present Assoc Professor, Dermatology, UTSWMC, Dallas, TX, 1993-7 Director, Pilot & Feasibility Studies Program, SDRC, UTSWMC, Dallas, TX 1993-2001 J.B. Shelmire Professor, Dermatology, UTSWMC, Dallas, TX, 1998- 2012 Chief, Dermatology Section (Medicine Service), Dallas VA Medical Center, Dallas, TX, 1997-present Vice Chair, Dermatology, UTSWMC, Dallas, TX, 1998-present Paul R. Bergstresser Endowed Chair, Dermatology, UT Southwestern Medical Center Dallas, TX, 2012-present
Other Experience and Professional Memberships Organizing Committee: Biologic Effects of Light Symposium, 1991-2004 Founding/Organizing Committee: Photomedicine Society, 1992-2005 Section Editor: Am J Contact Dermatitis, 1992-2002 Reviewer: NIH General Medicine I Study Section, 1995-9; ad hoc, 2000 Board of Directors: American Contact Dermatitis Society, 1996-9 President: Society for Investigative Dermatology Southern Region, 1997-8 Editorial Board: Arch Dermatol, 1995-2004 Reviewer: Dermatology Foundation Scientific Advisory Committee, 1995-8 Editor-in-chief: Dermatology Focus (publication of the Dermatology Foundation), 1995-2004 Editor-in-Chief: Dermatitis (formerly Am J Contact Dermatitis), 1999-2020 President: Photomedicine Society, 2003-6 | ||||
Associate Editor: J Am Acad Dermatol, 2004-8
Board of Directors: Society for Investigative Dermatology, 2004-8
Associate Editor: Photoderm Photoimmunol Photomed, 1990-8, 2004-present
Reviewer: NIH Special Emphasis Panel for Arthritis, Musculoskeletal and Skin Disease, 2005-9
Board of Directors: Association of Professors of Dermatology, 2012-5
Chair: Society for Investigative Dermatology Scientific Program Committee, 2015-7
President-elect, Society for Investigative Dermatology, 2018-9
Honors
Everett Fox Award for Best Paper by Research Fellow (American Academy of Dermatology), 1988 Outstanding Research Award (The Upjohn Company and the Dept of Dermatology, UTSWMC), 1989 Fitzpatrick Research Award (Kao Corporation), 1991-2
Young Leadership Award (American Dermatological Association), 1995
Medical Education Award: American Skin Association, 2012
Distinguished Teaching Professor: UT Medical System, 2013-present
PUBLICATIONS DURING THE PAST 3 YEARS.
- Chung J-S, Tamura K, Akiyoshi H, Cruz PD Jr., Ariizumi K: DC-HIL/Syndecan-4 pathway regulates autoimmune responses through myeloid-derived suppressor cells. J Immunol 192:2576-84, 2014.
- Lopez I, Turrentine J, Cruz PD Jr.: Clues to diagnosis of connubial contact dermatitis to para- phenylenediamine. Dermatitis 25:32-3, 2014.
- Chung J-S, Tamura K, Cruz PD Jr, Ariizumi K. DC-HIL-expressing myelomonocytic cells are critical promoters of melanoma growth. J Invest Dermatol 134:2784-94, 2014.
- Turrentine J, Chung J-S, Nezafati K, Tamura K, Harker-Murray A, Hugh J, Sharma RR, Harker DB, Ariizumi K, Cruz PD Jr. DC-HIL+ CD14+ HLA-DR no/low cells are a potential blood marker and therapeutic target for melanoma. J Invest Dermatol 134:2839-42, 2014.
- Owens J, Del Rosario E, Cruz PD Jr.: Conundrums of patch testing to Euxyl K400 and its components. Dermatitis 25:210, 2014.
- Nguyen R, Cruz PD Jr.: Hepatitis due to mycophenolate mofetil used to treat atopic dermatitis and allergic contact dermatitis. Dermatitis 25:284-5, 2014.
- Georgesen C, McDonough P, Cruz PD Jr.: Interstitial granulomatous dermatitis associated with gabapentin. Dermatitis 25:374-5, 2014.
- Word A, Nezafati K, Cruz PD Jr.: Treatment of warts with contact allergens. Dermatitis 26:32-7, 2015.
- Turrentine JE, Marrazzo G, Cruz PD Jr.: Novel use of patch testing in the first report of allergic contact dermatitis to cyclobenzaprine. Dermatitis 26:60-1, 2015.
- Patel S, Cruz PD Jr.: Topical irritant plus allergen for treatment of warts. Dermatitis 26:62, 2015.
- Carter ZA. Gordon K; Cruz PD Jr.: Erythroderma due to unwitting exposure to an unobvious allergen source. Dermatitis 26:291, 2015.
- Cao L, Chung J-S, Teshima T, Feigenbaum L, Cruz PD Jr., Jacobe H, Chong B, Ariizumi K: Myeloid-derived suppressor cells in psoriasis are an expanded population exhibiting diverse T cell- suppressor mechanisms. J Invest Dermatol 136(9):1801-10, 2016.
- Coffin S, Turrentine JE, Cruz PD Jr.: Photodermatitis for the allergist. Current Asthma Allergy Reports, 17(6):36, 2017.
- Feigenbaum L, Cruz PD Jr.: Acanthosis nigricans. In Lebwohl, Heymann, Berth-Jones,
Coulson, ed: Treatment of Skin Disease, 5th ed Elsevier Ltd, London, 2017, 1, 1-3
- Turrentine J, Cruz PD Jr.: Photoimmunology. In: Gaspari A., Tyring S., Kaplan D. (eds) Clinical and Basic Immunodermatology. Springer, Cham 2017, pp.151-163
- Turrentine J, Sheehan M, Cruz PD Jr.: Allergic contact dermatitis. In Fitzpatrick’s Dermatology in General Medicine, in press 2018.
- Ramani V, Teshima T, Tamura K, Chung JS, Kobayashi M, Cruz PD Jr., Ariizumi K. Melanoma-derived soluble DC-HIL/GPNMB promotes metastasis by excluding T lymphocytes from the pre-metastatic niches. J Invest Dermatol, doi: 10.1016/j.jid.2018.05.012.
- Kobayashi M, Chung JS, Beg M, Arriaga Y, Verma U, Courtney K, Mansour J, Haley B, Khan S, Horiuchi Y, Ramani V, Harker D, Gopal P, Araghizadeh F, Cruz PD Jr., Ariizumi K: Blocking monocytic myeloid-derived suppressor cell function via anti-DC-HIL/GPNMB antibody restores the in vitro integrity of T cells from cancer patients. Clin Cancer Res, doi: 10.1158/1078-0432.CCR-18-0330.
- Snyder M, Turrentine J, Cruz PD Jr.: Photocontact dermatitis and its clinical mimics: An overview for the allergist. Clin Rev Allergy Immunol, doi: 10.1007/s12016-018-8696-x.
REPRESENTATIVE EARLIER PUBLICATIONS PERTINENT TO THIS APPLICATION.
- Simon JC, Tigelaar RE, Bergstresser PR, Edelbaum D, Cruz PD Jr.: Ultraviolet B radiation converts Langerhans cells from immunogenic to tolerogenic antigen presenting cells: Induction of specific clonal anergy in CD4+ T helper 1 cells. J Immunol 146:485-91, 1991.
- Takao J, Ariizumi K, Dougherty I, Cruz PD Jr.: Genomic scale analysis of the human keratinocyte response to broad-band ultraviolet-B irradiation. Photodermatol Photoimmunol Photomed 18:5-13, 2002.
- Takao J, Yudate T, Das A, Shikano S, Bonkobara M, Ariizumi K, Cruz PD Jr.: Expression of NF-kB in epidermis and the relationship between NF-kB activation and inhibition of keratinocyte growth. Brit J Dermatol 148:680-8, 2003.
- Sato K, Yang X-L, Yudate T, Chung J-S, Wu J, Luby-Phelps K, Kimberly RP, Underhill D, Cruz PD Jr, Ariizumi K: Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor γ chain to induce innate immune responses. J Biol Chem 281(50):38854-66, 2006.
- Chung J-S, Sato K, Dougherty I, Cruz PD Jr, Ariizumi K. DC-HIL is a negative regulator of T cell activation. Blood 109:4320-4327, 2007.
- Chung J-S, Dougherty I, Cruz PD Jr, Ariizumi K. Syndecan-4 mediates the co-inhibitory function of DC-HIL on T cell activation. J Immunol 179:5778-84, 2007.
- Chung J-S, Bonkobara M, Tomihari M, Cruz PD Jr., Ariizumi K. The DC-HIL/syndecan-4 pathway inhibits human allogeneic T cell responses. Eur J Immunol 39: 965–974, 2009.
- Chung J-S, Yudate T, Tomihari M, Akiyoshi H, Cruz PD Jr, Ariizumi K. Binding of DC-HIL to dermatophytic fungi Induces tyrosine phosphorylation and potentiates antigen presenting cell function. J Immunol 183:5190-5198, 2009.
- Akiyoshi H, Chung J-S, Tomihari M, Cruz PD Jr, Ariizumi K. Depleting syndecan-4+ T lymphocytes using toxin-bearing DC-HIL: A new opportunity for treating activated T cell-driven disease. J Immunol 184: 3554 -3561, 2010.
- Tomihari M, Chung J-S, Akiyoshi H, Cruz PD Jr, Ariizumi K. DC-HIL/Gpnmb promotes growth of melanoma in mice by inhibiting activation of tumor-reactive T cells. Cancer Res 70:5778-5787, 2010.
- Chung J-S, Shiue LH, Duvic M, Pandya A, Cruz PD Jr, Ariizumi K. Sezary syndrome cells overexpress syndecan-4 bearing distinct heparan sulfate moieties that suppress T cell activation by binding DC-HIL and trapping TGF-b on the cell. Blood 117:3382-3390, 2011.
Financial relationships
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Date added:12/30/2021