William P. Cheshire is Professor of Neurology at the Mayo Clinic College of Medicine and since 1992 has been a consultant at the Mayo Clinic in Florida, where he specializes in autonomic neurology. He leads the Program in Professionalism & Values for Mayo Clinic's Florida campus in collaboration with colleagues across the Mayo enterprise nationally. In 2014 he served as President of the Staff of Mayo Clinic in Florida.

As an autonomic neurologist, Dr. Cheshire is Past President of the American Autonomic Society and an associate editor of Clinical Autonomic Research. He serves on the editorial board of Autonomic Neuroscience. He has also chaired the Autonomic Disorders Section of the American Academy of Neurology.

As a neuroethicist, Dr. Cheshire is a senior fellow at the Center for Bioethics & Human Dignity. He also chairs the Grievance Committee of the American Academy of Neurology. He is past chair of the Ethics Committee of the Christian Medical & Dental Associations. 

Dr. Cheshire has authored or coauthored more than 150 peer-reviewed publications in neurology and ethics and 30 book chapters.

Dr. Cheshire received his A.B. in biochemical sciences cum laude from Princeton University, his M.A. in bioethics summa cum laude from Trinity International University, and his M.D. from West Virginia University. He completed his neurology residency and pain fellowship at the University of North Carolina in Chapel Hill. He is board certified in Neurology by the American Board of Psychiatry and Neurology and in Autonomic Disorders by the United Council for Neurologic Subspecialties.

The Christian Medical & Dental Associations awarded him Educator of the Year in 2019. ​The neurology residents and fellows at Mayo Clinic in Florida awarded him teacher of the year in 2015.