I am a pulmonologist involved with multiple aspects of academic medicine, including clinical and applied basic research, clinical practice, and education.  I obtained my MD degree, followed by an internal medicine residency and a pulmonary medicine fellowship at the University of Toronto, Canada.  I moved to Dallas, Texas, for a research fellowship in pulmonary physiology, then became a faculty member. As a physician-scientist, my research interests center on the mechanisms of compensatory lung growth and strategies to maximize innate reparative and regenerative potential. With multi-disciplinary collaborators, we combine physiologic, morphometric, imaging, and cellular/molecular biology techniques to elucidate the stimuli of alveolar-capillary regrowth and remodeling and explore new therapeutics to improve outcomes. We developed noninvasive measurements of cardiopulmonary function in humans and animals,  quantified lung ultrastructure using CT and MRI in correlation to lung function and injury-repair in clinical disease, and examined molecular mechanisms of lung remodeling and re-growth. In addition to the original investigation, I spearheaded several Thoracic Society Task Forces outlining a) the signals, mechanisms, and limits of lung growth, b) the quantification of ex vivo lung ultrastructure by microscopy, and c) the in vivo imaging-derived metrics relating lung structure to pathophysiology. 

My clinical interests center on the granulomatous disease sarcoidosis; I have cared for patients with this diagnosis for many years and maintained an active Clinical Registry. UT Southwestern is a Foundation for Sarcoidosis Research Center of Excellence, and we are a founding member of the Global Sarcoidosis Clinic Alliance. As a subspecialty referral center, many of our patients suffer from multi-system sarcoidosis. We are active in conducting clinical trials and participating in a multi-center NHLBI study to examine biomarkers for predicting sarcoidosis progression and clinical outcomes.