EM1508D "Calciphylaxis: Controversies in Pathogenesis, Diagnosis and Treatment" (IM GR-082115)

Calcific uremic arteriolopathy, otherwise known as calciphylaxis, is a rare disease characterized by skin ulceration and tissue necrosis, likely the result of vascular calcification with accompanying intimal hypertrophy and small vessel thrombosis. Although most often associated with end stage renal disease, it has also been seen in a number of other disorders (collectively referred to as non-uremic calciphylaxis). The purpose of this review is to summarize and analyze the currently available literature regarding the pathophysiology, risk factors, clinical presentation, diagnostic features, and treatment modalities for this exceptionally uncommon illness. A series of recommended treatments is proposed for optimal treatment of calciphylaxis lesions.

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Target Audience

UT Southwestern faculty, fellows, residents and medical students, commnity physicians, nurse clinicians, physician assistants and nurses.

Learning Objectives

At the conclusion of this activity, the participant should be able to

  • Know risk factors associated with calciphylaxis.
  • Recognize the cutaneous features of calciphylaxis at each of its stages.
  • Understand the variability of the histopathology of calciphylaxis and its limits in diagnosis.
  • Understand the role of hypercoagulability in calciphylaxis and its effect on workup and treatment.
  • Recognize the need for multi-specialty care in patients with calciphylaxis.
Course summary
Available credit: 
  • 1.00 AMA
Course opens: 
Course expires: 

Photo: Arturo Dominguez, MDArturo Dominguez, MD
Assistant Professor
Department of Dermatology
Department of Internal Medicine

Available Credit

  • 1.00 AMA


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