EM1509L "Solid Tumor Second Malignancies as a Late Effect of Childhood Cancer Therapy" (IM GR-091115)

Current long-term survival of children with is now greater than 80%. As these young adults advance in age, they have unique medical needs and health risks that may go unheeded as they transition from pediatric care into general medical care. Their greatest risk of early mortality after short-term survival (5 years) of their original cancer is secondary malignancy related to their cancer therapy. This presentation attempts to demonstrate the heightened risk of subsequent cancer in this adult population throughout their lifespan, and to outline a clinical framework with which to approach that risk.

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Target Audience

UT Southwestern faculty, fellows, residents and medical students, commnity physicians, nurse clinicians, physician assistants and nurses.

Learning Objectives

At the conclusion of this activity, the participant should be able to

  • Recognize that the childhood cancer survivor population is growing in number every year, and is at risk of developing subsequent neoplasms across their lifespan.
  • Recognize that any radiation exposure confers an additional risk of subsequent cancer for childhood cancer survivors.
  • Recognize that in females treated with radiation for childhood Hodgkin Lymphoma, their risk of breast cancer parallels that of BRCA(+) women.
  • Recognize that specific cancer screening guidelines exist for this high-risk population.
Course summary
Available credit: 
  • 1.00 AMA
Course opens: 
Course expires: 

Photo: Angela Orlino, M.D.Angela Orlino, M.D.
Assistant Professor of Medicine
Division of General Internal Medicine

Available Credit

  • 1.00 AMA


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