EM1601E "Complement Dysregulation Related Renal Diseases" (IM GR012216)

This presentation aims to review tremendous advances made in our understanding of the dysregulation of complement alternative pathway in regards to renal disease mechanisms, heterogeneous phenotypic presentations, and potential therapeutic approaches.

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Target Audience

UT Southwestern faculty, fellows, residents and medical students, community physicians, nurse clinicians, physician assistants and nurses.

Learning Objectives

At the conclusion of this activity, the participant should be able to:

  • Review the complement system; focus on the alternative pathway (AP).
  • Review pathogenesis of kidney diseases caused by inappropriate activation of the AP: C3 glomerulopathies (C3GN and Dense Deposit Disease) and atypical HUS [aHUS]).
  • Review sites of dysregulation of the AP.
  • Review renal outcomes of C3 glomerulopathies and aHUS.
  • Differentiate aHUS from TTP.
  • Discuss new therapeutic options in kidney diseases caused by inappropriate activation of the AP.
  • Review renal transplantation outcomes in patients with HUS as a cause of ESRD
Course summary
Available credit: 
  • 1.00 AMA
Course opens: 
Course expires: 

Photo: Bekir Tanriover, M.D., M.P.H.Bekir Tanriover, M.D., M.P.H.
Assistant Professor
Division of Nephrolgy

Available Credit

  • 1.00 AMA


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