EM1704E "Weight Loss at Altitude-The Untold Story: It’s Cold Up Here!" (IM GR-041417)

Currently, there is a significant percentage of the population who are or will be classified as obese, necessitating novel strategies to facilitate sustainable weight loss. Reductions in basal metabolic rate occur in the face of weight loss, and pose formidable barriers to individuals attempting to sustain meaningful weight reductions. This grand rounds discusses the mechanisms by which non-shivering thermogenesis may provide insight into metabolic pathways that can become druggable targets to facilitate sustainable weight loss. Specifically highlighted is fact that non-shivering thermogenesis results in activation and expansion of brown and beige adipose tissues as well as activates pathways in skeletal muscle which increase metabolic flux and activity of muscle fibers through futile calcium cycling across the endoplasmic reticulum all facilitating an increase in metabolism. Finally, the protocol highlights the fact there are sexual dimorphisms with respect to these metabolic processes in keeping with the National Institutes of Health mandate of treating sex as a biologic variable.

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Target Audience

UT Southwestern faculty, fellows, residents and medical students, community physicians, nurse clinicians, physician assistants and nurses.

Learning Objectives

At the conclusion of this activity, the participant should be able to:

  • identify the metabolic changes that occur with weight reduction leading to increased skeletal muscle efficiency
  • list the metabolic pathways that characterize non-shivering thermogenesis in brown adipose tissue and skeletal muscle
  • identify the features that give rise to a sexual dimorphism in non-shivering thermogenesis
Course summary
Available credit: 
  • 1.00 AMA
Course opens: 
Course expires: 

Photo: Biff Palmer, M.D.Biff F. Palmer, M.D.
Professor of Internal Medicine
Division of Nephrology

Available Credit

  • 1.00 AMA


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