EM1707E "Cerebral Edema in Patients with Acute Liver and Renal Failure" (IM GR-072117)

Purpose of the presentation:

  1. To provide an overview of the pathogenesis of cerebral edema in patients with acute liver and renal failure, with special emphasis on the multifactorial nature of this condition.
  2. To provide an overview of the management of cerebral edema from a nephrologist’s perspective with a brief description of a novel approach for delivering osmotherapy.

Overview of the presentation:

The following topics will be covered chronologically:

  1. Epidemiology of acute liver failure.
  2. Clinical presentation of acute liver failure with emphasis on concomitant renal failure, hemodynamic instability, hyponatremia, and systemic inflammation.
  3. Pathogenesis of cerebral edema: role of the failed liver in generating cerebral edema; potential roles of the failed kidney, dialysis, hyponatremia, and systemic inflammation in worsening cerebral edema.
  4. Management of cerebral edema from a nephrologist’s perspective: effect of slow dialysis on intra-cranial pressures; description of dialysis-based osmotherapy and advantages over conventional delivery of osmotherapy

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Target Audience

UT Southwestern faculty, fellows, residents and medical students, community physicians, nurse clinicians, physician assistants and nurses.

Learning Objectives

At the end of the presentation, the listener should be able to understand the various mechanism that lead to water entry into the brain cells and development of cerebral edema, how cautious renal support can help provide stability and provide a novel approach for providing osmotherapy.

Course summary
Available credit: 
  • 1.00 AMA
Course opens: 
Course expires: 

Photo: Tamim Hamdi, M.D.Tamim Hamdi, M.D.
Assistant Professor of Medicine
Division of Nephrology

Available Credit

  • 1.00 AMA


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