IM1509N "A Garden Variety Case of Kidney Stones Viewed by a Clinical Physiologist" (IM GR-092515)

Using a very common cause of kidney stones as a starting point, an analysis of clinical physiology and pathophysiology is presented that espouse the view that physician are human biologists and the pathophysiologic approach to disease in fact renders the practice more interesting and also improves patient care. 

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Target Audience

UT Southwestern faculty, fellows, residents and medical students, commnity physicians, nurse clinicians, physician assistants and nurses.

Learning Objectives

At the conclusion of this activity, the participant should be able to:

  • Understad that Nephrolithiasis is not a diagnosis per se but a presentation of a diverse number of underlying conditions.
  • Understand how a calcium phosphate-based skeleton can have profound effects on many aspects of human physiology.
  • Understand the underlying biology for the dependence of urine calcium excretion on dietary sodium intake and the concept of physiologic hypercalciuria.
  • Understand the dual role of citrate in urine as a base and as the major chelator of calcium and conditions when there is conflict between these roles which forms the basis of dietary protein induced hypocitraturia.
  • Understand that extreme ranges of physiology can sometimes lead to undesirable phenotypes called “disease”.
Course summary
Available credit: 
  • 1.00 AMA
Course opens: 
Course expires: 

Photo: Orson Moe, M.D.Orson Moe, M.D.
Professor of Internal Medicine and Physiology
Division of Nephrology
The Charles Pak Distinguished Chair in Mineral Metabolism
Donald W. Seldin Professorship in Clinical Investigation

Available Credit

  • 1.00 AMA


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