EM2010F "Mutations in G Proteins and G Protein-coupled Receptors in Human Disease: Implications for Diagnosis and Treatment" (IM GR-100920)

I will give an introduction to the discovery, classification, structure and function of G Protein- coupled Receptors (GPCRs) and G proteins. I will illustrate how loss- and gain-of function mutations in G proteins and GPCRs cause of disease, and how GPCRs and to a lesser extent G proteins serve as targets for treatment of disease. Finally, I will focus on mutations in a unique GPCR, the calcium-sensing receptor, and in G11, the G protein to which it couples, and their importance in diagnosis and treatment of disorders of extracellular Ca++ metabolism.

Target Audience

UT Southwestern faculty, fellows, residents and medical students, community physicians, nurse clinicians, physician assistants and nurses.

Learning Objectives

At the conclusion of this activity, the participant should be able to:

  • Describe the variety, tissue distribution, and structure of GPCRs and G Proteins.
  • Identify clinical disorders caused by loss- and gain-of-function mutations in GPCRs and G Proteins.
  • Enumerate multiple examples of FDA-approved drugs that target GPCRs./li>
  • Identify hypercalcemic and hypocalcemic disorders caused by mutations in the calcium-sensing receptor and G11.
Course summary
Available credit: 
  • 1.00 AMA
Course opens: 
Course expires: 

Allen M. Spiegel, M.D.
Dean Emeritus
Professor of Medicine and Molecular Pharmacology
Albert Einstein College of Medicine
Arthur Grollman, MD, PhD Visiting Professorship in Experimental Medicine,
hosted by the Division of Endocrinology

Available Credit

  • 1.00 AMA


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