EM2112E "Defective Catabasis and the Post-Acute Sequelae of COVID" (IM GR-120321)

The purpose of this presentation is to provide updated information on the resolution of inflammation in health and the delayed resolution trajectories that comprise post-acute experiences after SARS-CoV-2 infection.

Target Audience

UT Southwestern faculty, fellows, residents and medical students, community physicians, nurse clinicians, physician assistants and nurses.

Learning Objectives

At the conclusion of this activity, the participant should be able to:

  • Explain how the resolution of inflammation is an active process with specific mediators and cellular effector mechanisms.
  • Describe in what way specialized pro-resolving mediators (SPMs) are a new genus of mediators that are enzymatically derived from essential polyunsaturated fatty acids and display anti-inflammatory, pro-resolving and host protective actions.
  • Review by what means SPM production is dysregulated during acute COVID-19.
  • Explain Post-Acute Sequelae of SARS-CoV-2 infection (PASC) as a clinical syndrome that is defined by symptoms that persist or emerge 30 days or more after acute infection, as well as exertional fatigue and dyspnea and neurocognitive disorders as the most common symptoms
  • Recall that PASC is most prevalent in patients that were hospitalized with acute COVID-19; however, even patients with mild acute infection can develop PASC.
Course summary
Available credit: 
  • 1.00 AMA
Course opens: 
Course expires: 

Bruce D. Levy, M.D.
Chief, Pulmonary and Critical Care Medicine
Medical Director, The Lung Center at BWH
Director, Lung Research Center at BRI
Brigham and Women’s Hospital/Harvard Medical School
Arthur G. Grollman Visiting Professorship in Experimental Medicine

Available Credit

  • 1.00 AMA


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