EM2309G "Autosomal Dominant Tubulointerstitial Kidney Disease" (IM GR-092923)

Purpose and Overview

Autosomal dominant tubulointerstitial kidney disease (ADTKD) is increasingly recognized as a prevalent genetic cause of chronic kidney disease (CKD). ADTKD is characterized by progressive renal insufficiency, tubular atrophy, and renal fibrosis without glomerular abnormalities. ADTKD is genetically heterogeneous and can be caused by mutations in at least six genes. This lecture will discuss the genetics, pathophysiology, clinical features, diagnosis, and treatment of ADTKD, focusing on the form caused by mutations of the transcription factor HNF1B.

Target Audience

UT Southwestern faculty, fellows, residents and medical students, community physicians, nurse clinicians, physician assistants and nurses.

Learning Objectives

At the conclusion of this activity, the participant should be able to:

  • Recognize the clinical and laboratory features of ADTKD.
  • List the genetic causes of ADTKD.
  • Describe how mutations of HNF1B produce kidney cysts, polyuria, and renal fibrosis.
Course summary
Available credit: 
  • 1.00 AMA
Course opens: 
10/03/2023
Course expires: 
11/03/2023
Cost:
$0.00
Rating: 
0

Photo: First Last, M.D.Peter Igarashi, M.D.
Dean, Renaissance School of Medicine
Dean, Renaissance School of Medicine
Stony Brook University

Available Credit

  • 1.00 AMA

Price

Cost:
$0.00
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Required Hardware/software

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