EM2402D “Molecular Mechanisms of Preeclampsia: Implications for Cardiovascular Disease and Chronic Kidney Disease” (IM GR-022324)

Purpose and Overview

Recent evidence suggests that the maternal syndrome of preeclampsia may be due to an imbalance in circulating angiogenic factors. The clinical manifestations of preeclampsia and their pathophysiological underpinnings with evidence that preeclampsia is an endothelial disease will be discussed. The central role of the placenta in the pathogenesis of preeclampsia as evidenced by defective placental pseudo-vasculogenesis and differentiation will be reviewed. We will then present evidence that excess soluble fms-like tyrosine kinase1 (sFlt1), an endogenous soluble inhibitor of VEGF signaling may play a causal role in the pathogenesis of preeclampsia. Circulating levels of sFlt1 and placental growth factor (PlGF), a ligand for sFlt1 may be used as markers for the early diagnosis of preeclampsia. We will discuss novel treatments such as therapeutic apheresis and RNA interference strategies targeting sFlt1 and aimed at shifting the balance in favor of pro-angiogenesis and endothelial health for this syndrome.  Finally, we will discuss the role of preeclampsia in mediating cardiovascular and chronic kidney disease. 

Target Audience

UT Southwestern faculty, fellows, residents and medical students, community physicians, nurse clinicians, physician assistants and nurses.

Learning Objectives

At the conclusion of this activity, the participant should be able to:

  • To understand the clinical manifestations of preeclampsia and their pathophysiologic underpin
  • To understand the role of endothelial growth factors in the pathogenesis of preeclampsia and to understand the implications of this knowledge for the diagnosis, prevention, and treatment of preeclampsia and other hypertensive disorders.
  • To understand the relationship between preeclampsia and long-term cardiovascular disease. 
Course summary
Available credit: 
  • 1.00 AMA
Course opens: 
Course expires: 

Photo: First Last, M.D.S. Ananth Karumanchi, M.B.B.S.
Medallion Chair in Vascular Biology
Director, Renovascular Research Center
Professor of Medicine
Cedars-Sinai Medical Center

Available Credit

  • 1.00 AMA


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