EM2409B "Harnessing the Microbiome for Understanding Inflammatory Arthritis" (IM GR - 090624)

Purpose and Overview

Despite strong associative evidence of a gut-joint axis driving inflammatory arthritis such as rheumatoid arthritis (RA) and spondyloarthritis (SpA), the specific mechanisms by which microbes or their products trigger intestinal immune dysregulation and ultimately inflammatory arthritis have not been elucidated. This presentation will discuss emerging hypotheses that connect microbial and mucosal changes associated with RA and SpA with the development of inflammation in the joint. Using specific examples of microbial translocation, impaired barrier permeability, education of mucosal and systemic immunity, and immune cell trafficking, we will discuss the possible mechanisms by which microbes can trigger arthritis.

Target Audience

UT Southwestern faculty, fellows, residents and medical students, community physicians, nurse clinicians, physician assistants and nurses.

Learning Objectives

At the conclusion of this activity, the participant should be able to:

  • Identify specific bacteria that can contribute to joint inflammation through molecular mimicry.
  • Describe how bacterial metabolism of dietary nutrients generates immunomodulatory products.
  • Summarize ways that the microbiome can trigger systemic disease.
Course summary
Available credit: 
  • 1.00 AMA
Course opens: 
09/10/2024
Course expires: 
10/10/2024
Cost:
$0.00
Rating: 
0

Photo: First Last, M.D. 
Kristi Kuhn, M.D. PHD
Professor of Medicine & Head of Rheumatology
University of Colorado School of Medicine

Available Credit

  • 1.00 AMA

Price

Cost:
$0.00
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Required Hardware/software

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