Acute Liver Failure: Science and Practice - Acute Liver Failure: Overview and Mechanisms of Liver Injury

Acute liver failure (ALF) is a rare but devastating condition that arises from diverse etiologies, has a high mortality and requires high resource utilization including transplantation. The Acute Liver Failure Study Group (ALFSG) has been funded by the National Institutes of Health (NIDDK) since 1997 to collect detailed clinical data on more than 3,500 ALF patients and closed its registry, database and bio-repository permanently in 2019.

This on-demand program, recorded at the 2-day live symposium, will provide a comprehensive review of all aspects of the pathogenesis and treatment of ALF including possible future therapies. Work pertaining to pathogenesis, epidemiology and patient evaluation, and further aspects of disease management (ICU management, treatment and consideration of prognosis, liver transplantation and liver support devices) will be reviewed. 

The target audience includes basic scientists that work on liver injury as well as clinicians (hepatologists, surgeons) who care for these very ill patients.

This course/program is endorsed by AASLD. The Acute Liver Failure Study Group is pleased to have received the endorsement of the American Association for the Study of Liver Diseases (AASLD). Copyright © 2022 by the American Association for the Study of Liver Diseases. All rights reserved.

DISCLAIMER
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of AASLD. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

METHOD OF PARTICIPATION
This continuing medical education enduring material is in a video format. 

In order to receive AMA PRA Category 1 Credit(s)™ and ABIM MOC points, you should:
1.    View the videos in this enduring material.
2.    Complete the posttests (A passing score of 75% is required).
3.    Complete and submit the CME evaluation form.

Eligible credit amounts are listed in each session. 

Hardware/software requirements: Activities should be run with recent versions of common browsers, including Internet Explorer, Mozilla Firefox, and Google Chrome.
If you have questions about the participation process, please e-mail the UT Southwestern Medical Center, cmeregistrations@utsouthwestern.edu.

Target Audience

THIS ACTIVITY IS INTENDED FOR PROVIDERS AND RESEARCHERS IN THE SPECIALTIES OF: 

  • Gastroenterology and Hepatology
  • Critical Care Medicine
  • Surgery
  • Anesthesiology

Learning Objectives

  • Explain basic factors that promote liver regeneration.
  • Discuss different mechanisms of liver injury and the role of genomics in susceptibility to acute liver failure.
Course summary
Available credit: 
  • 2.00 AMA
  • 2.00 Attendance
Course opens: 
10/03/2022
Course expires: 
09/30/2023
Cost:
$0.00
Rating: 
0

Session 1: Acute Liver Failure: Overview and Mechanisms of Liver Injury
2.0 AMA PRA Category 1 Credit(s)™
2.0 points in the ABIM MOC Program

Presentation Title

Speaker

Welcome to UTSW from the University President

Daniel Podolsky, M.D.

Introduction to the Meeting

Brendan McGuire, M.D.

Acute Liver Failure and the ALF Study Group:1997-2022

William M. Lee, M.D.

Molecular Mechanisms of Acute Liver Failure

Lily Dara, M.D.

Clinical Phenotypes of Acute Liver Failure

K. Rajender Reddy, M.D.

Histopathology of Acute Liver Failure

David E. Kleiner, M.D., Ph.D.

Course Directors, Moderators
 
William M. Lee, M.D.

Meredith Mosle Chair in Liver Disease in Honor of Dr. William M. Lee
Professor of Internal Medicine
UT Southwestern Medical Center

Brendan McGuire, M.D.
Medical Director of Liver Transplant
Professor
The University of Alabama at Birmingham

Speakers

William M. Lee, M.D.
Meredith Mosle Chair in Liver Disease in Honor of Dr. William M. Lee
Professor of Internal Medicine
UT Southwestern Medical Center

Lily Dara M.D.
Assistant Professor of Medicine
University of Southern California

K. Rajender Reddy, M.D.
Founders Professor of Medicine, Director of Hepatology
University of Pennsylvania

David E. Kleiner, M.D., Ph.D.
Senior Research Physician
Center for Cancer Research/NCI

Peer Reviewer

Brendan McGuire, M.D.
Medical Director of Liver Transplant
Professor
The University of Alabama at Birmingham

DISCLOSURE OF FINANCIAL RELATIONSHIPS 
 

As an organization accredited by the Accreditation Council for Continuing Medical Education (ACCME), The University of Texas Southwestern Medical Center, Office of Continuing Medical Education (UTSW CME) requires that the content of CME activities and related materials provide balance, independence, objectivity, and scientific rigor. Planning must be free of the influence or control of any ineligible company, and promote improvements or quality in healthcare.  In accordance with ACCME’s Standards for Integrity and Independence in Accredited Continuing Education, all persons in the position to control the content of an education activity are required to disclose all financial relationships in any amount occurring within the past 24 months with any ineligible company producing, marketing, re-selling, or distributing health care goods or services consumed by, or used on patients.  UT Southwestern also considers ineligible those companies producing, marketing, selling, re-selling, or distributing healthcare products in development for future use on patients, such as healthcare product research companies.  All reported financial relationships with ineligible companies are reviewed for relevancy and then mitigated through a content review process prior to the activity (where applicable).  
 
The following is a listing of all individuals that contributed to the educational content of this activity and any reported financial relationships within the last 24 months:

NAME
ROLE
RELATIONSHIP
COMPANY
William M. Lee, M.D.
Course Director, Moderator, Speaker
Grant or Contract
Grant or Contract
Grant or Contract
Grant or Contract
Grant or Contract
Grant or Contract
Grant or Contract
Grant or Contract
Independent Contractor
Independent Contractor
Independent Contractor
Independent Contractor
Independent Contractor
Merck
Intercept
Conatus
Novo Nordisk
IL
Alexion
Eiger
Gilead
Genentech
Forma Pharmaceuticals
Seattle Genetics
Karuna
Cortexyme
 
K. Rajender Reddy, M.D.
Speaker
Grant or Contract
Grant or Contract
Grant or Contract
Grant or Contract
Grant or Contract
Grant or Contract
Grant or Contract
Grant or Contract
Grant or Contract
Independent Contractor
Independent Contractor
Independent Contractor
Independent Contractor
Independent Contractor
Mallinckrodt
Exact Sciences
Gilead
Merck
Intercept
BMS
Grifols
Sequana
Biovie
Mallinkrodt
Novo Nordisk
Spark Therapeutics
Genfit
Novartis
 

 

 

The University of Texas Southwestern Medical Center is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Texas Southwestern Medical Center designates this enduring material activity for a maximum of 2.0 AMA PRA Category 1 Credits™.  Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 2.0 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

Eligible credit amounts are listed in each session.

Available Credit

  • 2.00 AMA
  • 2.00 Attendance

Price

Cost:
$0.00
Please login or create an account to take this course.

REGISTRATION

To register:

  1. Login to your existing account or create an account in EthosCE, online learning management system, by selecting the "create an account" link.
  2. Return to this course page and select the "Take Course" button.
  3. Registration will be completed.

Required Hardware/software

Activities should be run with recent versions of common browsers, including Internet Explorer, Mozilla Firefox, and Google Chrome.
If you have questions about the participation process, please e-mail the UT Southwestern Medical Center, cmeregistrations@utsouthwestern.edu.