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ForwardAcute Liver Failure: Science and Practice (RP2003B)
CANCELED - Due to recent events, the decision has been made by the course directors to cancel the planned meeting. Please stay tuned for a new date to be announced. Full refunds will be issued within the next 2 weeks.
Acute liver failure (ALF) is a rare but devastating condition that arises from diverse etiologies, has a high mortality and requires high resource utilization including transplantation.
The Acute Liver Failure Study Group (ALFSG) has been funded by NIDDK since 1997 to collect detailed clinical data on more than 3,500 patients, and has recently closed its registry and database for enrollments. It is an opportune time to take stock, consider where the field of study of ALF is going, what has been accomplished and to determine future directions of research in this unique syndrome. The audience would include basic scientists that work on liver injury and clinicians (hepatologists, surgeons) who care for these very ill patients.
This two-day program will provide a comprehensive understanding of all aspects of the pathogenesis and treatment of ALF including possible future therapies. The initial day of the meeting will be devoted to allowing investigators to present work pertaining to pathogenesis and disease mechanisms. The second day of the meeting will be devoted to reviewing aspects of disease management including evaluation, treatment and consideration of prognosis, liver transplantation and liver support devices.
This course/program is endorsed by AASLD. The Acute Liver Failure Study Group is pleased to have received the endorsement of the American Association for the Study of Liver Diseases (AASLD). Copyright © 2020 by the American Association for the Study Diseases. All rights reserved.
DISCLAIMER
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of AASLD. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Click here to view the full program brochure
Click here to view Exhibitor Prospectus
Target Audience
THIS ACTIVITY IS INTENDED FOR PROVIDERS IN THE SPECIALTIES OF:
Anesthesiology
Critical Care Medicine
Gastroenterology and Hepatology
Surgery
Learning Objectives
- Describe the differences between liver injury from Acetaminophen (APAP) vs. other drugs.
- Restate the role of cytokines in relation to injury evolution.
- Explain basic factors that promote liver regeneration.
- Explain the concept of sterile inflammation.
- Discuss different mechanisms of liver injury and the role of genomics in susceptibility to acute liver failure.
- Describe the current state of genome wide association studies. Review current state of identification of single nucleotide polymorphisms (SNPs) for specific diseases/drug injuries
- Review the elements of the basic and advanced work-ups for ALF patients.
- Identify natural history, differences in presentation, and how etiology drives prognosis and transplant decisions.
- Describe the circulatory and neurological physiology of ALF.
- Explain new understanding regarding hemostasis in ALF, management of kidney injury and hemostasis.
- Compare present treatment modalities and propose possible future management protocols.
- Contrast the differences in presentation and outcome of different etiologies.
- Relate how etiology drives prognosis and transplant decisions.
- Envision novel approaches to managing ALF in the future.
- Describe current issues surrounding liver support devices.
Additional Information
| Attachment | Size |
|---|---|
 Full program brochure | 250.69 KB |
| Exhibitor prospectus | 843.01 KB |
Monday March 30, 2020
Session 1: Acute Liver Failure: Overview and Mechanisms of Liver Injury
Moderators: Brendan McGuire, M.D. (UAB) and William M. Lee, M.D. (UTSW)
Time | Presentation Title | Speaker |
|---|---|---|
8-8:10 am | Welcome and Introduction | Brendan McGuire, M.D. |
8:10-8:30 am | Acute Liver Failure and ALFSG | William M. Lee, M.D. |
8:30-8:50 am | Acute Liver Failure Research: UK Perspective | Roger Williams, M.D., CBE |
8:50-9:10 am | Clinical Phenotypes of ALF | Raj Reddy, M.D. |
9:10-9:40 am | Histopathology of ALF | David Kleiner, M.D. |
9:40-10:00 am | Immune activation in pediatric ALF | Robert H. Squires, M.D. |
10:00-10:15 am | Discussion | |
Session 2: Liver Regeneration and Response to Injury
Moderators: Sanjeev Gupta, M.D. (Albert Einstein) and Michael Schilsky, M.D. (Yale)
Time | Presentation Title | Speaker |
|---|---|---|
10:30-10:55am | Overview of Basic Regenerative Mechanisms | Sanjeev Gupta, M.D. |
10:55-11:20 am | Immunologic Basis of Liver Injury/Response | Mark McPhail, M.D., UK |
11:20-11:40 am | Plasma Cells and Injury in HBV ALF | Patrizia Farci, M.D. |
11:45-12:15 pm | Bio-markers in ALF | Mike Schilsky, M.D. |
12:15-12:30 pm | Discussion |
|
Session 3: Genomics of Liver Injury
Moderators: Raymond Chung, M.D. (Mass General) and Robert Fontana, M.D. (U Michigan)
Time | Presentation Title | Speaker |
|---|---|---|
1:15-1:40 pm | Genomics Overview | Raymond Chung, M.D. |
1:40-2:05 pm | Genomics and Viral Liver Injury | Jean-Laurent Casanova, M.D.,PhD |
2:05-2:30 pm | Genomics of Drug-Induced Liver Injury | Paola Nicoletti, PhD |
2:30-2:45 pm | Discussion |
|
Session 4: Diagnosis and Evaluation of ALF
Moderators: Jim Hanje, M.D. (Ohio State) and Dan Ganger, M.D. (Northwestern University)
Time | Presentation Title | Speaker |
|---|---|---|
3:00-3:25 pm | Natural History of ALF | Ken Simpson, M.D. |
3:25-3:50 pm | Workup of Acute Liver Failure: Checklist | Oren Fix, M.D. |
3:50-4:15 pm | Case Presentation: New Diagnoses (HLH case) | Shannan Tujios, M.D. |
4:15-4:40 pm | Causality: Determining Etiology in ALF | Daniel Ganger, M.D. |
4:40-5:00 pm | Discussion |
|
Tuesday March 31, 2020
Session 5: Complications of ALF: Riding Out the Storm
Moderators: Dean Karvellas, M.D. (Univ. of Alberta) and Jody Olson, M.D. (Univ. of Kansas)
Time | Presentation Title | Speaker |
|---|---|---|
8:00-8:25 am | Critical Care of ALF: Overview | Dean Karvellas, M.D. |
8:25-8:50 am | Hemostasis in ALF: Is There a Coagulopathy? | R. Todd Stravitz, M.D. |
8:50-9:10 am | Fluids, Pressors, Kidney Injury Management | Jody Olson, M.D. |
9:10-9:30 am | Discussion |
|
Session 6: Prognosis in ALF/Role of Transplantation
Moderator: Ken Simpson, M.D. (Edinburgh) and David Koch, M.D. (MUSC)
Time | Presentation Title | Speaker |
|---|---|---|
9:45-10:10 am | Prognostic Indices: Determining Outcomes | David Koch, M.D. |
10:10-10:30 am | Designing Clinical Trials in an Orphan Disease | Valerie Durkalski, PhD |
10:30-10:55 am | Methacetin Breath Test and Other Tools | Robert Fontana, M.D. |
10:55-11:20 am | Outcomes of Transplantation: SRTR and ALFSG | Justin Parekh, M.D. |
11:20-11:45 am | Is ALF Going Away? An Epidemiologist’s View
| Babak Orandi, M.D. |
11:45-12:00 pm | Discussion |
|
Session 7: The Future of ALF: Newer Modalities of Liver Support
Moderator: R. Todd Stravitz, M.D. (MCV) and Scott Nyberg, M.D. (Mayo Clinic)
Time | Presentation Title | Speaker |
|---|---|---|
1:00-1:20 pm | Liver support machines: Current status | Scott Nyberg, M.D. |
1:20-1:40 pm | Stem cell recruitment for liver support | Russell Wesson, M.D. |
1:40-1:50 pm | Discussion | All |
1:50-2:00 pm | Final words | William M Lee, M.D. |
Parking: The parking garage is located adjacent to the T. Boone Pickens Biomedical Building. The garage entrance is to the right of the front building entrance. Use elevator to third floor and follow direction signs to the conference room.
Program accessibility: We accommodate people with disabilities. Please call 214-648-2166 for more information. To ensure accommodation, please register as soon as possible.
Course Directors:
William M. Lee, M.D.
Meredith Mosle Chair in Liver Disease in Honor of Dr. William M. Lee
Professor of Internal Medicine
UT Southwestern Medical Center
Brendan McGuire, M.D.
Medical Director of Liver Transplant
Professor
The University of Alabama at Birmingham
Planning Committee Members:
R. Todd Stravitz, M.D.
VCU Health
Robert J. Fontana, M.D.
University of Michigan Medical School
A. James Hanje, M.D.
The Ohio State University Wexner Medical Center
Constantine Karvellas, M.D.
University of Alberta
Jody Olson, M.D.
The University of Kansas Medical Center
The University of Texas Southwestern Medical Center is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The University of Texas Southwestern Medical Center designates this live activity for a maximum of 12.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
This course/program is endorsed by AASLD. The Acute Liver Failure Study Group is pleased to have received the endorsement of the American Association for the Study of Liver Diseases (AASLD). Copyright © 2020 by the American Association for the Study Diseases. All rights reserved.
DISCLAIMER
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of AASLD. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Available Credit
- 12.25 AMA
- 12.25 Attendance
Price
CANCELED - Due to recent events, the decision has been made by the course directors to cancel the planned meeting. Please stay tuned for a new date to be announced. Full refunds will be issued within the next 2 weeks.
REGISTRATION
- Physicians and General Registration $100
- Trainees $50
- Full-time UTSW Faculty and Staff ONLY - Complimentary
To register:
- Create an account in EthosCE, online learning management system, by selecting the "create an account" link at the bottom of the page or "log-in" to your existing account.
- Return to this course page, click "Register" tab, and select the designated fee.
- In the following "checkout" pages you will verify and process your payment.
- After registration is completed, a confirmation will be sent by email.
Refund Policy:
A $25 handling fee will be deducted from cancellation refunds. Refund requests must be received by email at cmeregistrations@utsouthwestern.edu by March 13, 2020. No refunds will be made thereafter.
**Limited onsite registration will be available