Acute Liver Failure: Science and Practice (RP2003B)

Dallas, TX US
March 30, 2020 to March 31, 2020

CANCELED - Due to recent events, the decision has been made by the course directors to cancel the planned meeting. Please stay tuned for a new date to be announced. Full refunds will be issued within the next 2 weeks.

Acute liver failure (ALF) is a rare but devastating condition that arises from diverse etiologies, has a high mortality and requires high resource utilization including transplantation.

The Acute Liver Failure Study Group (ALFSG) has been funded by NIDDK since 1997 to collect detailed clinical data on more than 3,500 patients, and has recently closed its registry and database for enrollments. It is an opportune time to take stock, consider where the field of study of ALF is going, what has been accomplished and to determine future directions of research in this unique syndrome. The audience would include basic scientists that work on liver injury and clinicians (hepatologists, surgeons) who care for these very ill patients.

This two-day program will provide a comprehensive understanding of all aspects of the pathogenesis and treatment of ALF including possible future therapies. The initial day of the meeting will be devoted to allowing investigators to present work pertaining to pathogenesis and disease mechanisms. The second day of the meeting will be devoted to reviewing aspects of disease management including evaluation, treatment and consideration of prognosis, liver transplantation and liver support devices.​​​​​​
 

This course/program is endorsed by AASLD.  The Acute Liver Failure Study Group is pleased to have received the endorsement of the American Association for the Study of Liver Diseases (AASLD). Copyright © 2020 by the American Association for the Study Diseases. All rights reserved.

DISCLAIMER
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of AASLD. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

 

Click here to view the full program brochure

Click here to view Exhibitor Prospectus

Target Audience

THIS ACTIVITY IS INTENDED FOR PROVIDERS IN THE SPECIALTIES OF: 
Anesthesiology
Critical Care Medicine
Gastroenterology and Hepatology
Surgery

Learning Objectives

  • Describe the differences between liver injury from Acetaminophen (APAP) vs. other drugs.
  • Restate the role of cytokines in relation to injury evolution.
  • Explain basic factors that promote liver regeneration.
  • Explain the concept of sterile inflammation.
  • Discuss different mechanisms of liver injury and the role of genomics in susceptibility to acute liver failure.
  • Describe the current state of genome wide association studies. Review current state of identification of single nucleotide polymorphisms (SNPs) for specific diseases/drug injuries
  • Review the elements of the basic and advanced work-ups for ALF patients.
  • Identify natural history, differences in presentation, and how etiology drives prognosis and transplant decisions.
  • Describe the circulatory and neurological physiology of ALF.
  • Explain new understanding regarding hemostasis in ALF, management of kidney injury and hemostasis.
  • Compare present treatment modalities and propose possible future management protocols.
  • Contrast the differences in presentation and outcome of different etiologies.
  • Relate how etiology drives prognosis and transplant decisions.
  • Envision novel approaches to managing ALF in the future.
  • Describe current issues surrounding liver support devices.

Additional Information

AttachmentSize
Full program brochure250.69 KB
Exhibitor prospectus843.01 KB
Course summary
Available credit: 
  • 12.25 AMA
  • 12.25 Attendance
Course opens: 
10/02/2019
Course expires: 
03/30/2021
Event starts: 
03/30/2020 - 7:00am
Event ends: 
03/31/2020 - 2:00pm
Cost:
$100.00

Monday March 30, 2020 
 

Session 1: Acute Liver Failure: Overview and Mechanisms of Liver Injury

Moderators: Brendan McGuire, M.D. (UAB) and William M. Lee, M.D. (UTSW)

Time

 Presentation Title

 Speaker

 8-8:10 am

 Welcome and Introduction

 Brendan McGuire, M.D.

 8:10-8:30 am

 Acute Liver Failure and ALFSG

 William M. Lee, M.D.

 8:30-8:50 am

 Acute Liver Failure Research: UK Perspective

 Roger Williams, M.D., CBE

 8:50-9:10 am

 Clinical Phenotypes of ALF

 Raj Reddy, M.D.

 9:10-9:40 am

 Histopathology of ALF

 David Kleiner, M.D.

 9:40-10:00 am

 Immune activation in pediatric ALF

 Robert H. Squires, M.D.

 10:00-10:15 am

 Discussion

 

Session 2: Liver Regeneration and Response to Injury

Moderators: Sanjeev Gupta, M.D. (Albert Einstein) and Michael Schilsky, M.D. (Yale)

Time

 Presentation Title

 Speaker

 10:30-10:55am

 Overview of Basic Regenerative Mechanisms

 Sanjeev Gupta, M.D.

 10:55-11:20 am

 Immunologic Basis of Liver Injury/Response

 Mark McPhail, M.D., UK

 11:20-11:40 am

 Plasma Cells and Injury in HBV ALF

 Patrizia Farci, M.D.

 11:45-12:15 pm

 Bio-markers in ALF

 Mike Schilsky, M.D.

 12:15-12:30 pm

 Discussion

 

 

Session 3: Genomics of Liver Injury

Moderators: Raymond Chung, M.D. (Mass General) and Robert Fontana, M.D. (U Michigan)

 Time

 Presentation Title

 Speaker

 1:15-1:40 pm

 Genomics Overview

 Raymond Chung, M.D.

 1:40-2:05 pm

 Genomics and Viral Liver Injury                   

 Jean-Laurent Casanova, M.D.,PhD

 2:05-2:30 pm

 Genomics of Drug-Induced Liver Injury

 Paola Nicoletti, PhD

 2:30-2:45 pm

 Discussion

 

 

Session 4: Diagnosis and Evaluation of ALF

Moderators: Jim Hanje, M.D. (Ohio State) and Dan Ganger, M.D. (Northwestern University)

 Time

 Presentation Title

 Speaker

 3:00-3:25 pm

 Natural History of ALF

 Ken Simpson, M.D.

 3:25-3:50 pm

 Workup of Acute Liver Failure: Checklist

 Oren Fix, M.D.

 3:50-4:15 pm

 Case Presentation: New Diagnoses (HLH case)

 Shannan Tujios, M.D.

 4:15-4:40 pm

 Causality: Determining Etiology in ALF

 Daniel Ganger, M.D.

 4:40-5:00 pm

 Discussion

 

 

Tuesday March 31, 2020 
 

Session 5: Complications of ALF: Riding Out the Storm

Moderators: Dean Karvellas, M.D. (Univ. of Alberta) and Jody Olson, M.D. (Univ. of Kansas)

Time

 Presentation Title

 Speaker

  8:00-8:25 am

 Critical Care of ALF: Overview

 Dean Karvellas, M.D.

  8:25-8:50 am

 Hemostasis in ALF: Is There a Coagulopathy?

 R. Todd Stravitz, M.D.

  8:50-9:10 am

 Fluids, Pressors, Kidney Injury Management

 Jody Olson, M.D.

  9:10-9:30 am

 Discussion

 

 

Session 6: Prognosis in ALF/Role of Transplantation

Moderator: Ken Simpson, M.D. (Edinburgh) and David Koch, M.D. (MUSC)

 Time

 Presentation Title

 Speaker

  9:45-10:10 am

 Prognostic Indices: Determining Outcomes

 David Koch, M.D.

 10:10-10:30 am

 Designing Clinical Trials in an Orphan Disease

 Valerie Durkalski, PhD

 10:30-10:55 am

 Methacetin Breath Test and Other Tools

 Robert Fontana, M.D.

 10:55-11:20 am

 Outcomes of Transplantation: SRTR and ALFSG

 Justin Parekh, M.D.

 11:20-11:45 am

 Is ALF Going Away? An Epidemiologist’s View

 

 Babak Orandi, M.D.

 11:45-12:00 pm

 Discussion

 

 

Session 7: The Future of ALF: Newer Modalities of Liver Support

Moderator: R. Todd Stravitz, M.D. (MCV) and Scott Nyberg, M.D. (Mayo Clinic)

Time

 Presentation Title

 Speaker

 1:00-1:20 pm

 Liver support machines: Current status

 Scott Nyberg, M.D.

 1:20-1:40 pm

 Stem cell recruitment for liver support

 Russell Wesson, M.D.

 1:40-1:50 pm

 Discussion

 All

 1:50-2:00 pm

 Final words

 William M Lee, M.D.

 

 

UT Southwestern Medical Center - T. Boone Pickens Biomedical Building Auditorium (NG3.112)
6001 Forest Park Rd.
Dallas, TX 75235
United States

Parking: The parking garage is located adjacent to the T. Boone Pickens Biomedical Building. The garage entrance is to the right of the front building entrance. Use elevator to third floor and follow direction signs to the conference room.

Program accessibility: We accommodate people with disabilities. Please call 214-648-2166 for more information. To ensure accommodation, please register as soon as possible.

Course Directors:

William M. Lee, M.D.
Meredith Mosle Chair in Liver Disease in Honor of Dr. William M. Lee
Professor of Internal Medicine
UT Southwestern Medical Center

Brendan McGuire, M.D.
Medical Director of Liver Transplant
Professor
The University of Alabama at Birmingham
 

Planning Committee Members:

R. Todd Stravitz, M.D.
VCU Health

Robert J. Fontana, M.D.
University of Michigan Medical School

A. James Hanje, M.D.
The Ohio State University Wexner Medical Center

Constantine Karvellas, M.D.
University of Alberta

Jody Olson, M.D.
The University of Kansas Medical Center

The University of Texas Southwestern Medical Center is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Texas Southwestern Medical Center designates this live activity for a maximum of 12.25 AMA PRA Category 1 Credits™.  Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

 

This course/program is endorsed by AASLD.  The Acute Liver Failure Study Group is pleased to have received the endorsement of the American Association for the Study of Liver Diseases (AASLD). Copyright © 2020 by the American Association for the Study Diseases. All rights reserved.

DISCLAIMER
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of AASLD. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Available Credit

  • 12.25 AMA
  • 12.25 Attendance

Price

Cost:
$100.00
Please login or create an account to take this course.

CANCELED - Due to recent events, the decision has been made by the course directors to cancel the planned meeting. Please stay tuned for a new date to be announced. Full refunds will be issued within the next 2 weeks.

REGISTRATION

  • Physicians and General Registration $100
  • Trainees $50
  • Full-time UTSW Faculty and Staff ONLY - Complimentary

To register:

  1. Create an account in EthosCE, online learning management system, by selecting the "create an account" link at the bottom of the page or "log-in" to your existing account.
  2. Return to this course page, click "Register" tab, and select the designated fee.
  3. In the following "checkout" pages you will verify and process your payment.
  4. After registration is completed, a confirmation will be sent by email.

How to use your coupon code?
 

Refund Policy:

A $25 handling fee will be deducted from cancellation refunds. Refund requests must be received by email at cmeregistrations@utsouthwestern.edu by March 13, 2020. No refunds will be made thereafter.

**Limited onsite registration will be available