Acute Liver Failure: Science and Practice (RP2205B)

Dallas, TX US
May 16, 2022 to May 17, 2022

Registration will close at 9 am Friday 5/13


Acute liver failure (ALF) is a rare but devastating condition that arises from diverse etiologies, has a high mortality and requires high resource utilization including transplantation. The Acute Liver Failure Study Group (ALFSG) has been funded by the National Institutes of Health (NIDDK) since 1997 to collect detailed clinical data on more than 3,500 ALF patients and closed its registry, database and bio-repository permanently in 2019. This is an opportune time to take stock, consider where the field of study of liver failure is going, what has been accomplished and to determine future directions of research in this unique syndrome. The audience would include basic scientists that work on liver injury as well as clinicians (hepatologists, surgeons) who care for these very ill patients.

This two-day program will provide a comprehensive review of all aspects of the pathogenesis and treatment of ALF including possible future therapies. The initial day of the meeting will be devoted to presenting work pertaining to pathogenesis, epidemiology and patient evaluation. The second day of the meeting will be devoted to reviewing further aspects of disease management: ICU management, treatment and consideration of prognosis, liver transplantation and liver support devices.
 

Interested in Exhibiting?

Click here to view the Exhibitor Registration Information Page
 

This course/program is endorsed by AASLD. The Acute Liver Failure Study Group is pleased to have received the endorsement of the American Association for the Study of Liver Diseases (AASLD). Copyright © 2022 by the American Association for the Study of Liver Diseases. All rights reserved.

DISCLAIMER
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of AASLD. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Target Audience

THIS ACTIVITY IS INTENDED FOR PROVIDERS AND RESEARCHERS IN THE SPECIALTIES OF: 

  • Gastroenterology and Hepatology
  • Critical Care Medicine
  • Surgery
  • Anesthesiology

Learning Objectives

  • Describe the differences between liver injury from acetaminophen (APAP) vs. other drugs.
  • Restate the role of cytokines in relation to injury evolution
  • Explain basic factors that promote liver regeneration.
  • Discuss different mechanisms of liver injury and the role of genomics in susceptibility to acute liver failure.
  • Describe the current state of genome wide association studies.
  • Review current state of identification of single nucleotide polymorphisms (SNPs) for specific diseases/drug injuries
     
  • Review the elements of the basic and advanced work-ups for ALF patients.
  • Identify natural history, differences in presentation, and how etiology drives prognosis and transplant decisions.
  • Describe the circulatory and neurological physiology of ALF.
  • Explain new understanding regarding hemostasis in ALF, management of kidney injury and hemostasis
  • Compare present treatment modalities and propose possible future management protocols.
  • Contrast the differences in presentation and outcome of different etiologies.
  • Relate how etiology drives prognosis and transplant decisions.
  • Envision novel approaches to managing ALF in the future.
  • Describe current issues surrounding liver support devices.

Additional Information

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PDF icon CME Handout962.85 KB
Course summary
Available credit: 
  • 10.25 AMA
  • 10.25 Attendance
Course opens: 
02/24/2022
Course expires: 
05/17/2023
Event starts: 
05/16/2022 - 8:00am CDT
Event ends: 
05/17/2022 - 12:00pm CDT
Cost:
$100.00

AGENDA

 

Acute Liver Failure: Science and Practice, a symposium.

Monday May 16, 2022 

 

Session 1: Acute Liver Failure: Overview and Mechanisms of Liver Injury

   Moderators: Brendan McGuire, MD (UAB) and William M. Lee, MD (UTSW)

Time

 Presentation Title

 Speaker

 8:00 - 8:05 am

Welcome to UTSW from the University President

 Daniel Podolsky, MD

 8:05 - 8:10 am

 Introduction to the Meeting

 Brendan McGuire, MD

 8:10 - 8:35 am

 Acute Liver Failure and ALFSG

 William M. Lee, MD

 8:35 - 9:00 am

 Mechanisms of Liver Injury

 Lily Dara, MD

 9:00 - 9:20 am

 Clinical Phenotypes of ALF

 Raj Reddy, MD

 9:20 - 9:40 am

 Acetaminophen Liver Injury: Current status

* This presentation is not approved for AMA PRA Category 1™ credit

 Laura James, MD, PhD

 9:40  - 10:00 am

 Histopathology of ALF

 David Kleiner, MD

 10:00 - 10:15 am

 Discussion

 

  Break
 

   Session 2: Liver Regeneration and Response to Injury

   Moderators: Adrian Reuben, MD (MUSC) and David Kleiner, MD (NCI)

Time

 Presentation Title

 Speaker

 10:30 - 10:50 am

 Overview of Basic Regenerative Mechanisms

 Sanjeev Gupta, MD

 10:50 - 11:15 am

 Immunologic Basis of Liver Injury/Response

 Evangelos Triantafyllou MD

 11:15 - 11:35 am

 Wnt Signaling and Regeneration

 Udayan Apte, PhD

 11:35 - 11:55 pm

 Pathophysiology of cerebral edema

 Chris Rose, PhD

 11:55 - 12:15 pm

 Discussion

 

 

Lunch Break – Visit Posters

 

Session 3: Genomics and Viral Discovery

    Moderators: Jorge Rakela, MD (Mayo Clinic) and Tony Bass, MD (UCSF)

 Time

 Presentation Title

 Speaker

 1:10 - 1:30 pm

 Viral Discovery in ALF

 Charles Chiu, MD

 1:30 - 1:50 pm

 Genomics and Viral Liver Injury                   

 Emmanuel Jouanguy, MD

 1:50 - 2:10 pm

 Genomics of Drug-Induced Liver Injury

* This presentation is not approved for AMA PRA Category 1™ credit

 Paola Nicoletti, PhD

 2:10 - 2:30 pm

 Biomarkers in ALF

 Jorge Rakela, MD

 2:30 - 2:45 pm

 Discussion

 

 

 

Break

 

 Session 4: Diagnosis, Evaluation and Prognosis of ALF

    Moderators: Bob Fontana, MD (Michigan) and Dan Ganger, MD (Northwestern)

 

 Time

 Presentation Title

 Speaker

 3:00 - 3:20 pm

 Natural History of ALF

 Adrian Reuben, MBBS

 3:20 - 3:40 pm

 Causality: Determining Etiology in ALF

 Daniel Ganger, MD

 3:40 - 4:10 pm

 Prognostic Indices: Determining Outcomes

 David Koch, MD

 4:10 - 4:30 pm

 Methacetin Breath Test/Other Prognostic Tools

 Robert J. Fontana, MD

 4:30 - 4:50 pm

 Discussion

 

 

Tuesday May 17, 2022 

 

Session 5: Complications of ALF: Riding Out the Storm

   Moderators: Iris Liou, MD (Univ. of Washington) and Bilal Hameed, MD (UCSF)

 

Time

 Presentation Title

 Speaker

  8:00 - 8:30 am

 Critical Care of ALF: Overview

 Dean Karvellas, MD

  8:30 - 8:50 am

 Hemostasis in ALF: Is There a Coagulopathy?

 Todd Stravitz, MD

  8:50 - 9:10 am

 The Decision to List for Transplant

 Shannan Tujios, MD

  9:10 - 9:30 am

 Outcomes of Transplantation: SRTR/ALFSG

 Dean Karvellas, MD

  9:30 - 9:45 am

 Discussion

 

 

Break
 

Session 6: Liver Support, Transplantation and The Future

    Moderator: Anne Larson, MD (Univ. of Washington) and William M. Lee, MD (UTSW)

 

 Time

 Presentation Title

 Speaker

 10:00 - 10:20 am

 Liver support machines: Current status

 Scott Nyberg, MD

 10:20 - 10:40 am

 Clinical trial of biologics for liver regeneration

 Russell Wesson, MD

 10:40 - 11:00 am

 Pediatric ALF: Current Status

 Jim Squires, MD

 11:00 - 11:20 am

 Is ALF Going Away? An Epidemiologist’s View

 Babak Orandi, MD

 11:20 - 11:40 am

 New agents for liver recovery

 Lars Zender, MD

 11:40 - 11:55 am

 Discussion

 

 11:55 - 12:00 pm

 Final Words

 William M. Lee, MD

 

 

UT Southwestern Medical Center - Excellence in Education Foundation Auditorium - Simmons Biomedical Research Building
6000 Harry Hines Blvd
Dallas, TX 75235
United States

PARKING

  • UTSW Faculty and staff should park in their designated locations, and utilize campus transportation where needed.
  • Visitors driving to campus may utilize a provided valet service at 6000 Harry Hines Blvd., Dallas, TX 75390 from 7:15 am to 5:15 pm on Monday and 7:30 to 12:15 on Tuesday.
  • Extremely limited self parking is available for a fee in a visitor parking garage at 6001 Forest Park Rd.

The Excellence In Education Foundation Auditorium is located on the 2nd floor in the Simmons Biomedical Research Building (NB) at 6000 Harry Hines Blvd., Dallas, TX 75390. 

Travel


BEFORE YOU COME

Stay at home if:

  •   You feel sick
  •   You have COVID-19 related symptoms
  •   You have a mild cough or low-grade fever (100° F/137.7° C or higher)

As a courtesy, please email us at CMERegistrations@utsouthwestern.edu should you not be able to attend the conference in person.

The University of Texas Southwestern Medical Center is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Texas Southwestern Medical Center designates this live activity for a maximum of 10.25 AMA PRA Category 1 Credits™.  Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

 

This course/program is endorsed by AASLD. The Acute Liver Failure Study Group is pleased to have received the endorsement of the American Association for the Study of Liver Diseases (AASLD). Copyright © 2022 by the American Association for the Study of Liver Diseases. All rights reserved.

DISCLAIMER
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of AASLD. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Available Credit

  • 10.25 AMA
  • 10.25 Attendance

Price

Cost:
$100.00
Please login or create an account to take this course.

REGISTRATION

  • Physicians and General Registration $100
  • Trainees $50
  • Full-time UTSW Faculty and Staff ONLY - Complimentary

To register:

  1. Create an account in EthosCE, online learning management system, by selecting the "create an account" link at the bottom of the page or "log-in" to your existing account.
  2. Return to this course page, click "Register" tab, and select the designated fee.
  3. In the following "checkout" pages you will verify and process your payment.
  4. After registration is completed, a confirmation will be sent by email.

How to use your coupon code?
 

Refund Policy:

A $25 handling fee will be deducted from cancellation refunds. Refund requests must be received by email at cmeregistrations@utsouthwestern.edu by May 6, 2022. No refunds will be made thereafter.

 

 


BEFORE YOU COME

Stay at home if:

  •   You feel sick
  •   You have COVID-19 related symptoms
  •   You have a mild cough or low-grade fever (100° F/137.7° C or higher)

As a courtesy, please email us at CMERegistrations@utsouthwestern.edu should you not be able to attend the conference.