The symposium is grounded in the concept of One Medicine, which hinges on harnessing insights from naturally occurring diseases in humans and animals to construct parallel, intelligent (smart) clinical trials across diverse disease domains, including oncology, musculoskeletal, and neurological disorders. By fostering collaboration and cross-disciplinary exchange, this approach has the potential to instigate a cultural shift in medical research and practice, reimagining traditional boundaries and expediting the clinical translation and utilization of therapeutic drugs and devices. The symposium - featuring plenary lectures, roundtable discussions, and graduate student/post-doc presentations - will offer attendees a unique opportunity to engage with cutting-edge advancements at the interface of human and veterinary medicine, thereby providing them critical insights and positioning them at the forefront of this evolving paradigm.